E16 CUTIS WWW.CUTIS.COM To the Editor: Granulomatous cheilitis (GC), also known as Miescher cheilitis, belongs to a larger class of diseases known as orofacial granulomatoses (OFGs), a set of diseases distinguished by their clinical and pathologic features of facial edema and granulomatous inflammation.1-3 Granulomatous cheilitis, a monosymptomatic variant of a more extensive disease known as M...

DOI 10.2146/news100005 Dyax Corp. on December 1 announced that FDA approved the marketing of the company’s ecallantide injection, or Kalbitor, for the treatment of acute attacks of hereditary angioedema in patients age 16 years or older. Ecallantide, the company said, binds to plasma kallikrein and blocks its binding site, resulting in less production of bradykinin, a vasodilator. According to ...

BACKGROUND Although certain drugs that target the renin- angiotensin-aldosterone system are linked to an increased risk for angioedema, data on their absolute and comparative risks are limited. We assessed the risk for angioedema associated with the use of angiotensin converting enzyme inhibitors (ACEIs), angiotensin receptor blockers (ARBs), and the direct renin inhibitor aliskiren. METHODS ...

Small bowel angioedema induced by angiotensin-converting enzyme (ACE) inhibitors is a rare clinicopathologic entity. It frequently poses a diagnostic challenge and is often not recognized before surgical exploration. The present study illustrates that clinical awareness for this condition and adequate use of radiologic investigations can help make the correct diagnosis of ACE inhibitor-associat...

The treatment of latent tuberculosis is part of the strategy to eliminate tuberculosis (TB) in low incidence countries.1 Ten to 15 million people in the United States have latent TB, and about 300,000 Americans are treated for it each year.2 The currently recommended treatments for latent TB include using the drugs isoniazid, rifampin, and rifapentine plus isoniazid.3,4 Rifampin was discovered ...

Sir, An 11-year-old girl presented in dermatology outdoor with facial edema, mainly affecting eyelids and lips [Figure 1], and widespread itchy urticarial lesions [Figure 2], accompanied with pain in the abdomen. There was no history of fever, chills, dizziness, and upper respiratory symptoms. She was a known case of type 1 diabetes mellitus and was regularly on insulin for the past 1 year. The...

Angioedema can cause potentially life-threatening airway obstruction. This case report describes an exceedingly rare episode of ticagrelor-induced hypersensitivity reaction, manifesting as angioedema with periorbital and likely respiratory involvement. The heart team should be vigilant for this precarious condition which may require emergent airway management. Desensitization protocols and alte...

Background Angioedema is defined as delimited edema that compromises dermis and subcutaneous. May have different causes hypersensitivity, autoimmune, idiopathic, physical factors, angiotensin-converting enzyme inhibitors and C1 esterase inhibitor consumption or disability. The physiopathologic mechanisms depend on the cause. In addition to detailed history, additional tests are needed for targe...

Angioedema is a potentially life-threatening adverse reaction to angiotensin-converting enzyme inhibitors and angiotensin receptor blockers. To study the genetic etiology of this rare adverse event, international consortia and multicenter recruitment of patients are needed. To reduce patient heterogeneity, we have standardized the phenotype. In brief, it comprises swelling in the head and neck ...

Angioedema is a common presentation with a broad differential, including rare disorders with which an allergist must be familiar. Our objective was to report a case of swelling of the hands and feet mimicking angioedema with hepatomegaly in a 4-year-old girl. The patient was evaluated for painful swelling of the hands and feet after exposure to sun. Examination revealed edema and erythema of th...