Background Local delivery of monocyte chemotactic protein-1 (MCP-1/CCL2) via our drug-eluting coil has been shown to promote intrasaccular aneurysm healing via an inflammatory pathway. Objective In this study, we validate the importance of local MCP-1 in murine aneurysm healing. Whether systemic, rather than local, delivery of MCP-1 can direct site-specific aneurysm healing has significant tr...

The paper includes a new concept of assessment of rupture risk of intracranial saccular aneurysms using geometric and hemodynamic parameters of aneurysm, artery and blood. Previous decision systems are mainly based on the size of aneurysm and frequency of subarrachnoid hemorrhages, therefore after performing simulation tests it has been proved that the complex assessment of clinical cases is po...

BACKGROUND A small aneurysm at an unusual location, such as a distal anterior inferior cerebellar artery (AICA) aneurysm, may conceal as a computed tomography angiography (CTA) and digital subtraction angiography (DSA)-occult aneurysm. CASE DESCRIPTION We herein present the case of a patient suffering from a subarachnoid hemorrhage (SAH) with two aneurysms in which the AICA aneurysm was negat...

BACKGROUND A doughnut-shaped aneurysm, which is defined as a round-shaped aneurysm composed of an intraluminar thrombus and marginal parent artery, is an extremely uncommon subtype of partially thrombosed giant aneurysms. Surgical treatment of this characteristic aneurysm is technically challenging. CASE DESCRIPTION We report a rare case of a 79-year-old man with a symptomatic doughnut-shaped...

Background: Aneurysm of the sinuses Valsalva (ASV) is a rare but potentially lethal condition. Young patients with aortic root aneurysm and normal valve are preferentially treated valve-sparing replacement (VSRR). However, this option may not be feasible in presence an ASV. We herein describe unique repair technique that allows ASV closure subsequent VSRR.

We herein report the first case of progressive perianeurysmal edema preceding the rupture of a small saccular aneurysm, without any intervention or intraluminal thrombosis. A 71-year-old woman was incidentally noted to have a cerebral aneurysm (5mm in diameter) at the lower basilar artery. Twelve months later, magnetic resonance (MR) imaging showed a T2-elongated area around a dome of the aneur...

Subarachnoid hemorrhage (SAH) is a potentially lethal disease with high morbidity and mortality. The goal of endovascular intracranial aneurysm treatment of intracranial aneurysms is the prevention of rebleeding after primary SAH, the prevention of SAH in unruptured aneurysms or the alleviation of other symptoms attributable to the aneurysm. Securing ruptured aneurysms improves outcome after SA...

BACKGROUND AND PURPOSE Noninvasive imaging identifying a predictive biomarker of the bleeding risk of unruptured intracranial aneurysms (UIAs) is needed. We investigated a potential biomarker of UIA instability, myeloperoxidase, in human aneurysm tissue. METHODS Human brain aneurysms were harvested after clipping and were histologically and biochemically evaluated for the presence of myeloper...

BACKGROUND AND PURPOSE The WEB device is an intrasaccular ellipsoid braided-wire embolization device designed to provide flow disruption along the aneurysm neck. The purpose of this study was to evaluate, in an in vivo aneurysm model, the acute and chronic performance of the WEB device regarding immediacy, degree, and durability of aneurysm occlusion. MATERIALS AND METHODS The WEB device was ...

Paraclinoidal aneurysms, especially superior hypophyseal artery (SHA) aneurysms (with medial projection), can be challenging to access via a pterional craniotomy and damage to the optic nerve can occur during surgery. The authors have previously reported on endonasal clipping and aneurysmorrhaphy of a vertebral artery aneurysm following proximal and distal protection of the aneurysm using parti...