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PHP3 INNOVATIVE HEALTHTECHNOLOGIES INTHE “ANTI-AGING-MEDICINE” FIELD: RESULTS FROMA SYSTEMATIC HORIZON SCANNING Storz P, Gothe H, Daroszewska A, Häussler B IGES Institut GmbH, Berlin, Germany OBJECTIVES: “Anti-Aging”, as an example of “preference oriented medicine”, is a currently much debated field. While it is sometimes perceived as beneficial in averting unwanted effects of aging, improving ...

Late-onset hypogonadism (LOH) in men is defined as ‘a clinical and biochemical syndrome, associated with advancing age and characterised by typical symptoms and a deficiency in serum testosterone levels’. Terms like ‘male climacterium’, ‘andropause’, or the ‘male menopause’ are misnomers of the condition, and their use is outdated. The testosterone deficiency may adversely affect the function o...

Although suppressed serum testosterone (T) is common in ageing men, only a small proportion of them develop the genuine syndrome of low T associated with diffuse sexual (e.g., erectile dysfunction), physical (e.g. loss of vigor and frailty) and psychological (e.g., depression) symptoms. This syndrome carries many names, including male menopause or climacterium, andropause and partial androgen d...

Osteoporosis is increasingly recognised in men. Low bone mass, risk factors for falling and factors causing fractures in women are likely to cause fractures in men. Bone mass is largely genetically determined, but environmental factors also contribute. Greater muscle strength and physical activity are associated with higher bone mass, while radial bone loss is greater in cigarette smokers or th...

Recent years have seen an increasing interest in the study of the aging male, with a particular interest in the problem of whether so-called rejuvenating hormones and, more specifically, androgens can improve quality of life, counteract progressive skeletal muscle loss and strength, prevent falls and fractures, prolong independent living, and reduce the dependence on medical care. Almost a deca...

10. Nair N, Oka RK, Waring LD et al. Vascular compliance versus flow-mediated dilatation: correlation with cardiovascular risk factors. Vasc Med 2005; 10: 275–83. 11. Wilkinson IB, MacCallum H, Cockcroft JR et al. Inhibition of basal nitric oxide synthesis increases aortic augmentation index and pulse wave velocity in vivo. Br J Clin Pharmacol 2002; 53: 189–92. 12. Stewart AD, Millasseau SC, Ke...

BACKGROUND Maintaining endogenous testosterone (T) levels as men age may slow the symptoms of sarcopenia, andropause and decline in physical performance. Drugs inhibiting the enzyme 5alpha-reductase (5AR) produce increased blood levels of T and decreased levels of dihydrotestosterone (DHT). However, symptoms of gynecomastia have been reported due to the aromatase (AER) enzyme converting excess ...

The aim of this study was to clarify the effects of yohimbine hydrochloride and three intracavernosal vasoactive agents in patients with erectile dysfunction and the effect of dihydrotestosterone gel in men with andropausal symptoms. The effect of transurethral resection of prostate (TURP) on sexual functions was also examined. Altogether 406 patients were included in five studies, and all pati...