T lymphocytes that are involved in cellular mediated immunity include two types known as TCD8+ (Cytotoxic T lymphocytes) and TCD4+ (helper T lymphocytes). TCD4+ has four main subtypes, including TH1, TH2, TH17, and Treg Lymphocytes.TH17 lymphocytes play a role in defense against microbes that TH1 and TH2 lymphocytes have not the ability to respond to them. The most important cytokines, which ar...

Alzheimer’s disease (AD) is a neurodegenerative disease characterized by cognitive and other CNS impairments which is increasing worldwide and poses a major public health problem, yet no effective treatments are found and available drugs only alleviate the symptoms temporarily. Postmortem analyses on the brains of AD patients and observed lower risk of AD in NSAIDs users among other studi...

background: systemic lupus erythematosus (sle) is a multisystem autoimmune disease. emerging data suggests that t helper 17 (th17) cells play a pathogenic role in sle and the increased number of these cells correlates with disease activity. in recent years, 1α, 25-dihydroxyvitamin d3 (1,25vitd3) has been considered as an immunomodulatory factor. objective: to investigate the effect of 1,25vitd3...

Background: Asphyxia is one of the main causes of infant mortality and long-term neurologic complications. This cohort study was aimed to compare the diagnostic value of the hematologic and biochemical factors in prediction of prognosis of asphyxia according to the high prevalence of asphyxia and its complications. Methods: In this cohort with two-year follow up study with availability samplin...

Imaginons que sur une planète éloignée qui s'appelle Marth, les symboles utilisés pour écrire les livres de mathématiques sont les seuls chiffres de 0 à 9. Il est bien connu que dans ces livres il n'y a que des vérités énoncées par des théorèmes. Un théorème Marthien ressemble donc à ceci : "108502054952". Pour nous cela est un nombre de 12 chiffres. Pour les Marthiens, ce n'est pas un nombre m...

It is well known that North Korea has been suffering from acute economic crises since the 1990's. Although the country's food shortage was revealed in 1995, North Korea had already been confronted with economic difficulties by then. The difficulties appear to have been chiefly caused by three changes in external trade patterns of North Korea. Firstly, at the beginning of the 1990's, North Korea...

We compare the experimental results of three stag-hunt games. In contrast to Battalio et al. (2001), our design keeps the riskiness ratio of the payoff-dominant and the risk-dominant strategies at a constant level as the optimisation premium is increased. We define the riskiness ratio as the relative payoff range of the two strategies. We find that decreasing the riskiness We would like to than...

Computer role-playing games (CRPGs) have strong narratives, but in general lack a density of interesting and meaningful choices for the player within the story. We have identified two main components of player interaction within the story—quests and character interaction—to address in a new playable experience, Mismanor. In this paper we focus on the character interaction aspect. In particular,...

Background: Interleukin 6 (IL-6) functions as both a pro-inflammatory cytokine and an anti-inflammatory cytokine. Objective: To evaluate the levels of IL-6 in patients with multiple organ dysfunction syndrome (MODS). Methods: Level of IL-6 was assessed and recorded for 14 days subsequent to the injury in 161 multiple trauma patients. MODS were diagnosed using Marshal Score. Injury Severity Scor...

Bakground: Multiple sclerosis (MS) is a CD4+ T cell-mediated autoimmune disease affecting the central nervous system (CNS). It was previously believed that Th1 cells were pathogenic T cells in experimental autoimmune encephalomyelitis (EAE). However, the functional role of Th1 cells in EAE has been reconsidered upon the discovery of IL-17- producing T cells which are consider as dominant effect...