Abstract Background Cutaneous wound healing and regeneration have become a recognized health challenge in the world, which causes severe damage to mental physical of patients. Human adipose-derived mesenchymal stem cells (hADSC) play an essential role via their paracrine function. Exosomes secreted by hADSC may contribute this progress. In study, we investigated potential clinical application r...

Materials Lambda exonuclease ( exo), Exonuclease I (exo I), Lambda Exonuclease Buffer and ThermoPolReaction Buffer were all purchased from New England Biolabs (MA, USA). Taq DNA polymerase was purchased from Tiangen Biotech Co. (Beijing, China). DNA strands were synthesized and purified by HPLC (Sangon Co., China). The sequences of all the probes and targets that have been studied in this work...

Agreement is a crucial component of many distributed systems. It is the feature that is at the center of critical algorithms that provide consensus, election, and failure detection, among others. Intuitively, agreement between processes is possible only in the presence of uninterrupted or well ordered operations. One such powerful primitive is atomic, or ‘total order,’ broadcast. The way in whi...

Exosome, a micro-vesicle, has role to maintain cell-cell communication in paracrine manner and can induce cell proliferation differentiation. Recently exosome mediated differentiation gain attraction development biology due transfer mRNA miRNA recipient cell. But it remains unclear whether adipose derived stem cells (ASCs) could adopt the dermal papilla (DP) like properties with (DPC-Exo). To u...

Mesenchymal stem cells (MSCs) have potential application for the treatment of ischemic heart diseases. Besides differentiation properties, MSCs protect ischemic cardiomyocytes by secretion of paracrine factors. In this study, we found exosomes enriched with miR-22 were secreted by MSCs following ischemic preconditioning (Exo(IPC)) and mobilized to cardiomyocytes where they reduced their apoptos...

Bicyclo[3.2.0]hept-2-enes undergo thermal rearrangement to norbornenes via diradical transition structures. The synthesis of exo-7-cyclopropylbicyclo[3.2.0]hept-2-ene has been achieved by cycloaddition of cyclopentadiene and cyclopropylketene, generated by treatment of cyclopropylacetyl chloride with triethylamine. A comparison of the cyclopropyl substituent effect with that of other C7 substit...

The endo/exo-dichotomy in the domain of the material world is analyzed from the standpoint of old-fashioned Cartesian dualism. The holistic structure of the quantum world enforces a Platonic view for the universally valid laws governing matter. In contrast to the structural simplicity of non-operational quantum endophysics, the empirical reality and experiments belong to quantum exophysics. In ...