Caffeine is a commonly used food additive found naturally in many products. In addition to potently stimulating the central nervous system caffeine is able to affect various systems within the body including the cardiovascular and respiratory systems. Importantly, caffeine is used clinically to treat apnoea and bronchopulmonary dysplasia in premature babies. Recently, caffeine has been shown to...

The effects of caffeine (0.2-10 mM) on the electrical and mechanical activities of guinea pig taenia coli were investigated with the double sucrose-gap method. Caffeine evoked a small tension with a latency of 20-30 sec, then phasic contraction developed and finally relaxation. The initial tension development also appeared in the Na-free solution without any marked changes in the membrane poten...

Phytoremediation is an efficient approach that uses plants to remediate the polluted environments.The aim of this research was to evaluate phytoremediation ability of Artemisia aucheriin the contaminated soil to Cadmium, Lead, Zinc and Nickel. A greenhouse experiment was performed to investigate the effect of Municipal Solid Waste Compost (MSWC) on phytoremediation efficiency of A....

The effect of ephedrine at 0 (E0C0, n = 10), 8 (E8C0, n = 10) and 10 (E10C0, n = 10) mg per kg metabolic body weight or mixture of ephedrine/caffeine, at doses of 8 mg ephedrine/80 mg caffeine (E8C80, n = 10), or 10 mg ephedrine/100 mg caffeine (E10C100, n = 7), per kg metabolic body weight on body composition of feedlot Mehraban ram lambs (8-month-old) was studied. The lambs were fed for 95 da...

troencephalography (EEG) in rats. First, the stimulatory action by caffeine i.y. administratlon at a level higher than 5"mollkg (O.970 mg!kg) b.w. was shown by means of brain wave analysis, and this level was suggested as the minim"m dese of caffeine as a stimulant. Next, the stimulatory effects of caffeine were inhibited by an i.v. administration of theanine at a level higher than 5pmol!kg (O....

OBJECTIVES We studied whether caffeine impairs protection by ischemic preconditioning (IP) in humans. BACKGROUND Ischemic preconditioning is critically dependent on adenosine receptor stimulation. We hypothesize that the adenosine receptor antagonist caffeine blocks the protective effect of IP. METHODS In vivo ischemia-reperfusion injury was assessed in the thenar muscle by 99mTc-annexin A5...

AIM The aim of this study was to evaluate the effect of caffeine on collagen biosynthesis in human skin fibroblasts and the influence of hyaluronic acid (HA) on this process. MATERIALS AND METHODS Collagen, [(3)H]-thymidine incorporation, and prolidase activity were measured in confluent human skin fibroblast cultures that had been treated with 1, 2, and 5 mM caffeine and with caffeine and 50...

Enhanced cytogenetic damage by cyclophosphamide (CP) was observed when Ehrlich ascites tumor cells were exposed in vivo to nontoxic concentrations of caffeine. One h before i.p. injection of 5-bromodeoxyuridine adsorbed to activated charcoal Ehrlich ascites tumor-bearing mice treated i.p. with CP appear to have a dose-dependent increase in sister chromatid exchange rates and cell division delay...

In this randomized blinded study, we investigated caffeine 5 mg/kg treatment given directly after neonatal brain hypoxia ischemia. Brain morphology, behavior and key brain infiltrating immune populations were examined. Caffeine treatment significantly improves outcome when compared to phosphate buffered saline. Flow cytometric analysis of immune responses revealed no persistent immunological al...

The Chinese commonly believe that tea helps maintain clear vision. This viewpoint has been recorded in Chinese medical books also. The key bioactive compounds in green tea leaves, (-)-epigallocatechin gallate (EGCG), L-theanine (theanine) and caffeine, were investigated for their abilities to attenuate the injury of retinal ganglion cells (RGC-5) induced by H2O2 and ultraviolet radiation. Thean...