The anthelmintic pyrantel plays an important role in the control of gastrointestinal helminths of humans and domestic animals. Despite the demonstration of pyrantel resistance in several helminth species over the last 20 years, the resistance mechanism remains unclear. It has been hypothesized that resistance may arise as a consequence of changes to the relative proportions of subpopulations of...

The hookworms Necator americanus and Ancylostoma duodenale infect approximately 1 billion people worldwide. The prevalence of hookworm infection increases with age in children, typically reaching a plateau in late adolescence, whereas the intensity of infection may continue to increase throughout adulthood. Hookworms cause intestinal blood loss in amounts proportional to the number of adult wor...

BACKGROUND Humans can get infected through direct or indirect contact with infective stages of zoonotic parasites shed to the environment through dog faeces. OBJECTIVES This study was designed to investigate the presence of gastrointestinal parasites present in dog faeces shed on the street of Ibadan metropolis, one of the largest cities in Africa. METHODS Twenty-three locations were random...

Intestinal nematodes are among the most common parasites of dogs, being Toxocara spp. and Ancylostoma spp. threats to public health due to their zoonotic potential. In this study, three parasitological diagnostic techniques for detecting the eggs/oocysts of canine intestinal parasites were evaluated. Fecal samples (n = 285) were collected from the environment (i.e. public streets, squares and h...

Accepted: 05/09/2013 Abstract Twenty four lions of Nandankanan Zoo were studied for prevalence of nematode eggs by faecal sample analysis and the prevalence rate was found to be 70%. For evaluation of anthelmintics, 20 lions were considered and were divided into four groups according to the drug administered and each group consisted of five animals. The lions were administered pyrantel pamoate ...

The Syrian Golden hamster (Mesocricetus auratus) has been used to model infections with the hookworm Ancylostoma ceylanicum. New molecular immunological reagents to measure cellular immune responses in hamsters were developed and used to determine the impact of A. ceylanicum hookworm infection on host cytokine responses and lymphoproliferation. Initial larval infection with 100 third-stage A. c...

Blood-feeding parasites employ a battery of proteolytic enzymes to digest the contents of their bloodmeal. Host haemoglobin is a major substrate for these proteases and, therefore, a driving force in the evolution of parasite-derived proteolytic enzymes. This review will focus on the digestive proteases of the major blood-feeding nematodes - hookworms (Ancylostoma spp. and Necator americanus) a...

The anthelmintic activity of thiabendazole syrup against Ancylostoma duodenale was investigated. Hookworm carriers (192) from the inhabitants of a village in Yamanashi Prefecture were treated under three dosage schedules. Before and after the administration, for the purpose of assessment, fecal examinations were performed by the thick smear method, the brine floatation method and quantitative d...

BEHNKE J. M., ROSE R. and LITTLE J. 1994. Resistance of the hookworms Ancylostoma ceylanicum and Necator americanus to intestinal inflammatory responses induced by heterologous infection. International Journalfor Parasitology 24: 91-101. Experiments were carried out to ascertain whether the acute inflammatory phase of the intestinal response of hamsters to infection with Trichinella spiralis wo...

Hookworms infect nearly a billion people. The Ancylostoma caninum hookworm of canids is a model for studying human infections and information from its genome coupled with functional genomics and proteomics can accelerate progress towards hookworm control. As a step towards a full-scale A. caninum genome project, we generated 104,000 genome survey sequences (GSSs) and determined the genome size ...