Vancomycin is an antibiotic used primarily For staphylococcal infections. It also is recommended by the American Heart Association For the prevention of subacute bacterial endocarditis in susceptible patients who are allergic to penicillin. Anaphylactic reactions to vancomycin are rare, with only two cases reported in the literature. A case of an anaphylactic reaction to vancomycin in a chiht p...

The activation of profibrinolysin in sensitized guinea pig serum when mixed in vitro with the homologous antigen was confirmed with a more accurate and more reliable method than the one previously used. A study was made of some of the conditions required for obtaining maximum activation. Profibrinolysin activation was also induced in normal guinea pig serum by addition of certain "anaphylactoid...

Polyoxyethyleneglycerol triricinoleate (Cremophor EL; CrEL) is a liquid product formed by the reaction of ethylene oxide with castor oil at a molar ratio of 35:1 [1]. CrEL is used as a excipient in formulations for the solubilization of various hydrophobic drugs including anesthetics [2], antineoplastic agents [2,3] immunosuppressive agents [4], analgesics [5,6] vitamins [7] and new synthetic w...

taxenes, platinum salts, L-asparaginase and monoclonal antibodies involving anaphylactic or anaphylactoid reactions. To date no desensitisation protocols have been published on third generation aromatase inhibitors like AN. In these case reports both patients referred late reactions to AN with mainly cutaneous symptoms. To clarify the underlying mechanism of these reactions, patch tests with 10...

The purpuras of Henoch and Schonlein have usually been described together under the term ' anaphylactoid purpura." It is only in recent times, however, that papers on their pathology have appeared in which a definite lesion, which is common to both conditions, is described. This consists of an arteriolitis which, in severe cases, is necrotizing. It is now reasonably well established that the Sc...