The oncoprotein v-Myb of avian myeloblastosis virus (AMV) transforms myelomonocytic cells by deregulating specific target genes. Previous work has shown that the oncogenic potential of v-Myb was activated by truncation of N- and C-terminal sequences of c-Myb and was further increased by amino acid substitutions in the DNA-binding domain and other parts of the protein. We have analyzed the activ...

A novel Cl-dependent Na/H exchange (Cl-NHE) has been identified in apical membranes of crypt cells of rat distal colon. The presence of Cl is required for both outward proton gradient-driven Na uptake in apical membrane vesicles (AMV) and Na-dependent intracellular pH recovery from an acid load in the crypt gland. The present study establishes that Cl-dependent outward proton gradient-driven (2...

Abstract Recent analysis of pantropical interactions suggests that after 1980 the tropical Atlantic Ocean’s (TAO) influence on Pacific Ocean (TPO) appears to have become much more pronounced while Indian (TIO) weakened. This study explores whether and how decadal changes in TAO TPO SSTs modulate these connections an attempt explain recent dominance TAO. To this end, we carry out a series ideali...

The advent of the Meteosat Second Generation (MSG) provides many new opportunities for improved derivation of Atmospheric Motion Vectors (AMVs) from geostationary satellite data. MSG will provide full field of view imagery data every 15 min. with a sampling distance of 3 km, already improving the capabilities to derive AMVs. Another main improvement is the large range of available channels that...

Chide helper factor (chf) negative chick embryo cells were exposed in the presence of DEAEdextran to chromosomal DNA isolated from avian leukemic myeloblasts which had been induced by infection with the BAI-A strain of avian myeloblastosis virus (AMV) (subgroup B ). After several transfers, avian C-type virus production was observed in the cultures with electron micro­ scopy, although no altera...

The oncogenic properties of sarcoma, acute leukemia, and lymphatic leukemia viruses are interpreted in terms of their genetic structures. Highly oncogenic sarcoma and acute leukemia viruses are shown to contain transforming onc genes which are different from the three virion genes (gag, pol, and env) essential for replication. Biochemical and genetic approaches to define onc genes are discussed...

Niacin (vitamin B3; nicotinic acid) plays an important role in maintaining redox state of cells and is obtained from endogenous and exogenous sources. The latter source has generally been assumed to be the dietary niacin, but another exogenous source that has been ignored is the niacin that is produced by the normal microflora of the large intestine. For this source of niacin to be bioavailable...

Reverse transcriptase of RNA tumor viruses plays an important role in the integration of the viral genome into host cell DNA1,2) and specific inhibitors of this enzyme might provide chemotherapeutic agents against infection by retro viruses. In the course of our screening for enzyme inhibitors against reverse transcriptase of avian myeloblastosis virus (AMV), the novel substances, retrostatin3)...

Multipartite plant viruses were discovered because of discrepancies between the observed dose response and predictions of the independent-action hypothesis (IAH) model. Theory suggests that the number of genome segments predicts the shape of the dose-response curve, but a rigorous test of this hypothesis has not been reported. Here, Alfalfa mosaic virus (AMV), a tripartite Alfamovirus, and tran...