background: the purpose of this study is to evaluate effects of teucrium polium (tp) leaf extracts on adenosine monophosphate activated protein kinase (ampk) level in isolated pancreases. materials and methods: in this experimental study, two groups of rats were used as a control group, and diabetic group. in the end of experimental period the animals were sacrificed then pancreas were removed,...

Glycogen phosphorylase has been studied in Rana pipiens eggs and embryos with regard to the nature of the enzyme, its control possibilites, and its involvement in preneurula development. On the basis of enzyme activity, immunological, and electrophoretic comparisons, R. pipiens egg phosphorylase is not wholly identical with the phosphorylases characteristic of skeletal muscle, liver, or kidney ...

The energy sensor AMP-activated protein kinase (AMPK) is activated by metabolic stress and restores ATP levels in cells by switching off anabolic and switching on catabolic pathways. Recent discoveries demonstrate that AMPK is activated primarily by rising ADP levels and not, as previously thought, by AMP. AMPK activation is dependent on ADP-controlled phosphorylation of Thr172 on its activatio...

Abbreviations: ACC s acetyl-CoA carboxylase; AMP-PK s protein serinerthreonine kinase activated by 5-AMP; CPT-I s carnitine palmitoyltransferase-I; CREB protein s cyclic AMP-response element binding protein; ERKs s extracellular signal-regulated kinases: the MAP kinases originally Ž identified are now known to represent a sub-set of a wider family; the original members of the family are now ref...

Glycogen phosphorylase has been studied in Rana pipiens eggs and embryos with regard to the nature of the enzyme, its control possibilites, and its involvement in preneurula development. On the basis of enzyme activity, immunological, and electrophoretic comparisons, R. pipiens egg phosphorylase is not wholly identical with the phosphorylases characteristic of skeletal muscle, liver, or kidney ...

RATIONALE AMP-activated protein kinase is a master regulator of cell metabolism and an attractive drug target for cancer and metabolic and cardiovascular diseases. Point mutations in the regulatory γ2-subunit of AMP-activated protein kinase (encoded by Prkag2 gene) caused a unique form of human cardiomyopathy characterized by cardiac hypertrophy, ventricular preexcitation, and glycogen storage....

OBJECTIVE The endoplasmic reticulum (ER) plays a critical role in ensuring proper folding of newly synthesized proteins. Aberrant ER stress is reported to play a causal role in cardiovascular diseases. However, the effects of ER stress on vascular smooth muscle contractility and blood pressure remain unknown. The aim of this study was to investigate whether aberrant ER stress causes abnormal va...

oxymatrine, a potent monosomic alkaloid extracted from chinese herb sophora japonica (sophora flavescens ait.). possesses anti-inflammatory activittyes.  this study was designed to investigate the effects of oxymatrine on nuclear factor–kappa b (nf-κb) and mitogen-activated protein kinase (mapk)-dependent inflammatory responses in lipopolysaccharide (lps)-activated microglia. in this paper, bv2...