Limited continuous replenishment of the mineralization medium is a restriction for in-situ solution-based remineralization of hypomineralized body tissues. Here, we report a process that generated amine-functionalized mesoporous silica nanoparticles for sustained release of biomimetic analog-stabilized amorphous calcium phosphate precursors. Both two-dimensional and three-dimensional collagen m...

Calcium phosphate nanoparticles are highly biocompatible and biodegradable in bone regeneration. On the other hand, strontium magnesium enhance formation of bone. The substitution calcium by is an efficient way to improve biological properties phosphate-based biomaterials. Strontium-doped magnesium-doped with degrees cation 5, 10, 15, 20 mol% respect were prepared precipitation, followed surfac...

BACKGROUND The authors undertook a study to measure how the addition of amorphous calcium phosphate (ACP) to a professionally dispensed 16 percent carbamide peroxide equivalent bleaching gel affects tooth color and dentinal hypersensitivity. METHODS The authors assigned two groups to use either the test gel containing ACP or a control gel. Both groups used their respective products for three ...

AIM To evaluate the effect of amorphous calcium phosphate (ACP)-containing pit and fissure sealant on inhibition of enamel demineralization in vitro. MATERIALS AND METHODS Enamel specimens (n = 75) were prepared using freshly extracted noncarious human third molars. Box-shaped cavities (8 × 2 × 2 mm) on the buccal or lingual surfaces were prepared and restored with resin-based sealant (Concis...

In article 2200097, J. Wang, D. Li, Q. Xu, H. C. Liang, X. Zhang, S.-B. A. Chen, and N. Jiang prepare platinum/mesoporous silica/amorphous calcium phosphate core-shell nanostructures (Pt@mSiO2@CaP), loaded by doxorubicin hydrochloride (DOX), for synergistic chemo- photothermal therapy. The DOX-Pt@mSiO2@CaP is internalized in the lysosomes of U-87 MG cells efficiently releases DOX cells. under n...

A new composite of poly(methyl methacrylate) – co -(ethyl-hexyl-acrylate) filled with glass of composition (wt.%) 61,33% 3CaO.P2O5 23,03% SiO2 – 15,64% MgO was developed. The formation of CaP (calcium phosphate) layers on implants is crucial for their integration in bone. Simulated biological fluids to study in vitro formation of those layers do not usually contain important organic substances,...

The present survey deals with the initial stage of the calcification process in bone and other hard tissues, with special reference to the organic-inorganic relationship and the transformation that the early inorganic particles undergo as the process moves towards completion. Electron microscope studies clearly exclude the possibility that these particles might be crystalline structures, as oft...

In human bone, an amorphous mineral serves as a precursor to the formation of a highly substituted nanocrystalline apatite. However, the precise role of this amorphous mineral remains unknown. Here, we show by using transmission electron microscopy that 100-300 nm amorphous calcium phosphate regions are present in the disordered phase of trabecular bone. Nanomechanical experiments on cylindrica...

Despite the importance of siRNA delivery systems, understanding of their intracellular fate remains elusive. We recently developed a multi-component siRNA nanocomplex to deliver siRNA to hepatic stellate cells (HSCs). The objective of this study is to study post-internalization trafficking of this siRNA nanocomplex and its multiple components like siRNA, protamine, and streptavidin, in HSCs. Af...