The syntheses of 1-N-(S-4-amino-2-hydroxybutyryl)-gentamicin B and 1-N-(S-3-amino-2-hydroxypropionyl)-gentamicin B, designated sch 20287 and Sch 21420, respectively, by procedures similar to those developed by KAWAGUCHI and co-workers for the transformation of kanamycin A to amikacin are described. The in vitro microbiological properties of Sch 20287 and Sch 21420 are compared with amikacin, ge...

Citation: Broussou DC, Lacroix MZ, Toutain P-L, Woehrlé F, El Garch F, Bousquet-Melou A and Ferran AA (2018) Differential Activity of the Combination of Vancomycin and Amikacin on Planktonic vs. Biofilm-Growing Staphylococcus aureus Bacteria in a Hollow Fiber Infection Model. Front. Microbiol. 9:572. doi: 10.3389/fmicb.2018.00572 Differential Activity of the Combination of Vancomycin and Amikac...

Enterobacteriaceae strains having elevated minimal inhibitory concentrations (greater than or equal to 2.0 to less than or equal to 32 micrograms/ml) of cefoperazone, cefotaxime, ceftazidime, and moxalactam were synergistically inhibited by amikacin combinations (54.1 to 69.6% occurrence). Indifference was rare (8.1% for moxalactam), and true antagonistic interactions were not observed. Strains...

Mở đầu: Amikacin là kháng sinh trong nhóm aminoglycosid được sử dụng các trường hợp nhiễm khuẩn Gram âm nặng. Mục tiêu: Khảo sát tình hình amikacin và đánh giá tính phù hợp, độc trên thận của việc amikacin. Đối tượng phương pháp: Nghiên cứu cắt ngang mô tả thực hiện 288 hồ sơ bệnh án nhân (BN) 18 tuổi và có sử dụng ít nhất 3 ngày từ 01/06/2020 đến 30/12/2020 tại viện Nhân dân Gia Định. Dữ liệu ...

RATIONALE In experimental pneumonia, nebulization of antibiotics provides high lung tissue concentrations and rapid bacterial killing. OBJECTIVES To assess the efficacy and safety of nebulized ceftazidime and amikacin in ventilator-associated pneumonia caused by Pseudomonas aeruginosa. METHODS Forty patients with ventilator-associated pneumonia caused by Pseudomonas aeruginosa were included...

The aminoglycosides kanamycin and amikacin and the macrocyclic peptide capreomycin are key drugs for the treatment of multidrug-resistant tuberculosis (MDR-TB). The increasing rates of resistance to these drugs and the possible cross-resistance between them are concerns for MDR-TB therapy. Mutations in the 16S rRNA gene (rrs) have been associated with resistance to each of the drugs, and mutati...

BACKGROUND AND PURPOSE Isepamicin is a newly introduced aminoglycoside in Taiwan. Since in vitro data for isepamicin against nosocomial Gram-negative bloodstream infection from Taiwan are limited, we compared the activity of isepamicin, amikacin, gentamicin and tobramycin against nosocomial Gram-negative blood isolates. METHODS A total of 247 non-duplicate nosocomial blood isolates of Gram-ne...