A practical synthesis of (3R,3aS,6aR)-hexahydrofuro[2,3-b]furan-3-ol-a key intermediate in the synthesis of darunavir-from monopotassium isocitrate is described. The isocitric acid salt, obtained from a high-yielding fermentation fed by sunflower oil, was converted in several steps to a tertiary amide. This amide, along with the compound's ester functionalities, was reduced with lithium aluminu...

A long-standing challenge in synthetic chemistry is the development of the transamidation reaction. This process, which involves the conversion of one amide to another, is typically plagued by unfavourable kinetic and thermodynamic factors. Although some advances have been made with regard to the transamidation of primary amide substrates, secondary amide transamidation has remained elusive. He...

Dual-carbon batteries (DCBs), in which both the positive and negative electrodes are composed of carbon-based materials, promising next-generation owing to their limited usage scarce metals high operating voltages. In typical DCBs, metal cations anions electrolytes consumed simultaneously at electrodes, respectively, can rapidly deplete charge carrier ions electrolytes. this study, solve challe...

The conversion of rac -phenylglycinonitrile by different variants the nitrilase from Pseudomonas fluorescens EBC191 (EC 3.5.5.1) was studied and amounts chiral composition formed phenylglycine amide compared. Muteins that converted to extraordinarily high or were tested for chemoenzymatic enantioselective one-pot synthesis ( R )- S )-phenylglycine amide. combined initial step in traditional che...

The lipid intermediates in peptidoglycan synthesis in Sfaphylococcus aureus, N-acetyhuuramyl(-pentapeptide)-PP-lipid and N-acetylglucosaminyl-N-acetyhnuramyl(-pentapeptide)-P-P-lipid, act as acceptors of ammonia in an ATP-dependent reaction in which the ar-carboxyl group of glutamic acid is amidated. Procedures have been developed for the separation of the amide and the amide-free forms of the ...

The lipid intermediates in peptidoglycan synthesis in Sfaphylococcus aureus, N-acetyhuuramyl(-pentapeptide)-PP-lipid and N-acetylglucosaminyl-N-acetyhnuramyl(-pentapeptide)-P-P-lipid, act as acceptors of ammonia in an ATP-dependent reaction in which the ar-carboxyl group of glutamic acid is amidated. Procedures have been developed for the separation of the amide and the amide-free forms of the ...

Fatty acid amide hydrolase (FAAH) is a mammalian integral membrane enzyme that degrades the fatty acid amide family of endogenous signaling lipids, which includes the endogenous cannabinoid anandamide and the sleep-inducing substance oleamide. FAAH belongs to a large and diverse class of enzymes referred to as the amidase signature (AS) family. Investigations into the structure and function of ...

Imidazoline and its precursor, amide, are very effective inhibitor intermediates and are widely used in formulating the corrosion products for application in the oil and gas industries. Their high temperature corrosion inhibition performance was evaluated and compared. Our results show that imidazoline and amide offer poor to moderate high temperature/pressure (300 °F/3,000 psig) inhibition per...

Herein we show that San A-amide, a structurally unique molecule, influences a subset of cancer-related pathways involving Hsp90. We show that San A-amide specifically binds to the N-middle domain of Hsp90 allosterically disrupts the binding of proteins thought to interact with the Hsp90 C-terminal domain, while having no effect on an N-terminal domain client protein. This unique mechanism sugge...

A straightforward heteronuclear pseudo-3D NOESY-HSQC pulse sequence using radiation damping to selectively invert magnetization at the water frequency was developed to estimate the amide proton exchange rates in 15N-labelled proteins. The peak intensities in the resultant 2D spectrum allow a direct classification of amide proton exchange rates according to short (ms), intermediate (ms to s) or ...