STUDY OBJECTIVE To evaluate a new method of closed-loop mechanical ventilation using an adaptive lung ventilation (ALV) controller in patients with different pathologic causes of respiratory failure at a time when they first met standard weaning criteria. STUDY DESIGN Prospective, open, selected case study. SETTING The 10-bed, multidisciplinary respiratory intensive care unit at Groote Schu...

Avian leukosis virus (ALV) has been used as a model system to understand the mechanism of pH-independent viral entry involving receptor-induced conformational changes in the viral envelope (Env) glycoprotein that lead to membrane fusion. Here, we report the unexpected finding that ALV entry depends on a critical low pH step that was overlooked when this virus was directly compared to the classi...

Viral envelope (Env)-receptor interactions have been implicated in the cell death associated with infection by subgroups B and D avian leukosis-sarcoma viruses (ALVs). A chicken protein, CAR1, was identified that permitted infection of mammalian cells by these viral subgroups. CAR1 bound to a viral Env fusion protein, comprising an ALV-B surface Env protein and the Fc region of an immunoglobuli...

It is a fundamental decision making process in container terminals to allocate container transporting works among ALVs. Nowadays, container terminals tend to be larger in storage space and more efficient in handling. As a result, estimations of ALV travel times could be inaccurate, the scale of ALV work allocation could be quite large, and a fixed handling sequence could be hardly ensured befor...

Alveolar rhabdomyosarcoma, a malignant tumor of skeletal muscle, is characterized by a chromosomal translocation, t(2;13)(q35;q14). This translocation is associated with a structural rearrangement of the gene encoding PAX3, a presumed transcriptional regulator expressed exclusively during embryogenesis. The breakpoint results in a fusion between PAX3 and a gene provisionally named ALV, a novel ...

An intelligent approach to autonomous land vehicle (ALV) guidance in outdoor road environments using combined line and road following and color information clustering techniques is proposed. Path lines and road boundaries are selected as reference models, called the line-model and the road-model, respectively. They are used to perform linemodel matching (LMM) and road-model matching (RMM) to lo...

Antibody-based therapeutics have now had success in the clinic. The affinity and specificity of the antibody for the target ligand determines the specificity of therapeutic delivery and off-target side effects. The discovery and optimization of high-affinity antibodies to important therapeutic targets could be significantly improved by the availability of a robust, eukaryotic display technology...