Alu and B1 repeats are mobile elements that originated in an initial duplication of the 7SL RNA gene prior to the primate-rodent split about 80 million years ago and currently account for a substantial fraction of the human and mouse genome, respectively. Following the primate-rodent split, Alu and B1 elements spread independently in each of the two genomes in a seemingly random manner, and, ac...

In this paper, we present: 1) design of a single-rail energy-efficient 64-b Han–Carlson ALU, operating at 482 ps in 1.5 V, 0.18m bulk CMOS; 2) direct port of this ALU to 0.18m partially depleted SOI process; 3) SOI-optimal redesign of the ALU using a novel deep-stack quaternary-tree architecture; 4) margining for max-delay pushout due to reverse body bias in SOI designs; and 5) performance scal...

Exonization of Alu elements creates primate-specific genomic diversity. Here we combine bioinformatic and experimental methodologies to reconstruct the molecular changes leading to exon selection. Our analyses revealed an intricate network involved in Alu exonization. A typical Alu element contains multiple sites with the potential to serve as 5' splice sites (5'ss). First, we demonstrated the ...

Several features make Alu insertions a powerful tool used in population genetic studies: the polymorphic nature of many Alu insertions, the stability of an Alu insertion event and, furthermore, the ancestral state of an Alu insertion is known to be the absence of the Alu element at a particular locus and the presence of an Alu insertion at the site that forward mutational change. This study ana...

The signal recognition particle (SRP) Alu domain has been implicated in translation elongation arrest in yeasts and mammals. Fission yeast SRP RNA is similar to that of mammals, but has a minimal Alu-domain RNA lacking two stem-loops. The mammalian Alu-domain proteins SRP9 and SRP14 bind their cognate Alu RNA as a heterodimer. However, in yeasts, notably Saccharomyces cerevisiae, SRP14 is thoug...

This paper looks into various metrics discussed in the designs of multiple different ALUs, such as the Clock gated ALU, the ALU utilizing Vedic Multiplier in its MAC unit, and the scalable DCT architecture ALU. The discussion of these designs and the subsequent metrics that will be analyzed will cover both time and space complexity, as well as the general desire for every new design to use less...

The Past fifteen years have seen an extraordinary increase in ALU and floating point unit technology, from space efficiency to power management. In order to quantify some of these changes, several research papers authored over a decade and a half were collected for study and analysis. Measurements of interest included Power consumption of ALU, ITRS technology node width, Execution time per ALU,...

The 3' untranslated regions (3' UTRs) of transcripts serve as important hubs for posttranscriptional gene expression regulation. Here, we find that the exonisation of intergenic Alu elements introduced new terminal exons and polyadenylation sites during human genome evolution. While Alu exonisation from introns has been described previously, we shed light on a novel mechanism to create alternat...

Newly isolated members of two recently propagated (young) Alu subfamilies were examined for sequence diversity and insertion polymorphism in primate genomes. The smaller subfamily (termed HS-2) is comprised of approximately 5 to 25 members, while the larger (termed Sb2) includes approximately 125 to 600 members. Individual members of these Alu subfamilies share distinguishing sets of diagnostic...

A significant fraction of Alu repeats in human sperm DNA, previously found to be unmethylated, is nearly completely methylated in DNA from many somatic tissues. A similar fraction of unmethylated Alus is observed here in sperm DNA from rhesus monkey. However, Alus are almost completely methylated at the restriction sites tested in monkey follicular oocyte DNA. The Alu methylation patterns in ma...