نتایج جستجو برای: als

تعداد نتایج: 27090  

2017
Sung-Min Kim Min-Young Noh Heejaung Kim So-Young Cheon Kang Mi Lee Jaeick Lee Eunju Cha Kyung Seok Park Kwang-Woo Lee Jung-Joon Sung Seung Hyun Kim

This study aimed to evaluate the levels of three major hydroxycholesterols (24-, 25-, and 27-hydroxycholesterols) in the serum and cerebrospinal fluid (CSF) of patients with amyotrophic lateral sclerosis (ALS), as well as to show their role in the pathogenesis of ALS experimental models. The level of 25-hydroxycholesterol were higher in untreated ALS patients (n = 30) than in controls without A...

2010
Alvaro Alonso Giancarlo Logroscino Susan S Jick Miguel A Hernán

BACKGROUND Previous epidemiologic studies have examined the association of smoking with amyotrophic lateral sclerosis (ALS) incidence, but their results have been inconsistent. Moreover, limited information exists on the association between smoking and survival in ALS patients. We evaluated the association of smoking with ALS incidence and survival in a population-based cohort. METHODS We con...

Journal: :Archives of neurology 2009
Biba R Stanton Daisy Shinhmar Martin R Turner Victoria C Williams Steven C R Williams Camilla R V Blain Vincent P Giampietro Marco Catani P Nigel Leigh Peter M Andersen Andrew Simmons

BACKGROUND The basis of heterogeneity in the clinical presentation and rate of progression of amyotrophic lateral sclerosis (ALS) is poorly understood. OBJECTIVES To use diffusion tensor imaging as a measure of axonal pathologic features in vivo in ALS and to compare a homogeneous form of familial ALS (homozygous D90A SOD1 [superoxide dismutase 1]) with sporadic ALS. DESIGN Cross-sectional ...

2015
Caroline Ingre Per M Roos Fredrik Piehl Freya Kamel Fang Fang

Amyotrophic lateral sclerosis (ALS) is the most common motor neuron disease. It is typically fatal within 2-5 years of symptom onset. The incidence of ALS is largely uniform across most parts of the world, but an increasing ALS incidence during the last decades has been suggested. Although recent genetic studies have substantially improved our understanding of the causes of ALS, especially fami...

2009
Beatrice Nefussy Irena Artmonov Vivian E. Drory Nora Chan Jess Ting

OBJECTIVE: Review the literature from 2003 to 2006 to determine if new data change the conclusions of a previous review (Neuroepidemiology 2003; 22:217-228) that sports and trauma are probably (“more likely than not”) not risk factors for developing ALS. BACKGROUND: Reported apparent excess occurrence of ALS in professional Italian soccer players has rekindled the discussion, whether sports or ...

2015
Jerome Deval Jin Hong Guangyi Wang Josh Taylor Lucas K. Smith Amy Fung Sarah K. Stevens Hong Liu Zhinan Jin Natalia Dyatkina Marija Prhavc Antitsa D. Stoycheva Vladimir Serebryany Jyanwei Liu David B. Smith Yuen Tam Qingling Zhang Martin L. Moore Rachel Fearns Sushmita M. Chanda Lawrence M. Blatt Julian A. Symons Leo Beigelman Sean Whelan

Respiratory syncytial virus (RSV) causes severe lower respiratory tract infections, yet no vaccines or effective therapeutics are available. ALS-8176 is a first-in-class nucleoside analog prodrug effective in RSV-infected adult volunteers, and currently under evaluation in hospitalized infants. Here, we report the mechanism of inhibition and selectivity of ALS-8176 and its parent ALS-8112. ALS-...

2010
Olli-Pekka Ryynänen Timo Iirola Janne Reitala Heikki Pälve Antti Malmivaara

BACKGROUND Prehospital care is classified into ALS- (advanced life support) and BLS- (basic life support) levels according to the methods used. ALS-level prehospital care uses invasive methods, such as intravenous fluids, medications and intubation. However, the effectiveness of ALS care compared to BLS has been questionable. AIM The aim of this systematic review is to compare the effectivene...

Journal: :International journal of clinical and experimental pathology 2015
Yuting Ren Wenjia Zhu Fang Cui Fei Yang Zhaohui Chen Li Ling Xusheng Huang

The diagnosis of amyotrophic lateral sclerosis (ALS) is mainly based on clinical and electrophysiological features. It is yet to be confirmed if cystatin C (Cys-C) can be a candidate diagnostic biomarker for ALS. This retrospective study aimed at investigating the changes in the level of Cys-C levels in the cerebrospinal fluid (CSF) of Chinese patients with ALS. CSF and serum samples obtained f...

2017
Jane Alana Parkin Kullmann Roger Pamphlett

OBJECTIVES The ratio of the length of the index finger (2D) to the ring finger (4D) (2D:4D) has been reported to be lower (ie, 2D<4D) in people with amyotrophic lateral sclerosis (ALS) than non-ALS controls. This has led to suggestions that exposure to increased prenatal testosterone, which also lowers this ratio, could be a risk factor for ALS. In an attempt to test this hypothesis, we examine...

2013
Sung-Min Kim Heejaung Kim Jeong-Seon Lee Kyung Seok Park Gye Sun Jeon Jeeheun Shon Suk-Won Ahn Seung Hyun Kim Kyung Min Lee Jung-Joon Sung Kwang-Woo Lee

BACKGROUND Patients with ALS may be exposed to variable degrees of chronic intermittent hypoxia. However, all previous experimental studies on the effects of hypoxia in ALS have only used a sustained hypoxia model and it is possible that chronic intermittent hypoxia exerts effects via a different molecular mechanism from that of sustained hypoxia. No study has yet shown that hypoxia (either chr...

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