نتایج جستجو برای: alpha er

تعداد نتایج: 251424  

Journal: :Endocrinology 2002
Heike Brand Martin Kos Stefanie Denger Gilles Flouriot Jörg Gromoll Frank Gannon George Reid

The role of estrogens in the development and physiology of the male reproductive tract remains provocative, with a growing body of evidence suggesting that estrogens are able to influence normal testis development and physiology, through their classical receptors, estrogen receptor (ER)-alpha and ER-beta. We describe the identification and characterization of a new promoter that is involved in ...

Journal: :Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 2003
Qiuyin Cai Xiao-Ou Shu Fan Jin Qi Dai Wanqing Wen Jia-Rong Cheng Yu-Tang Gao Wei Zheng

Estrogen receptor (ER) is a ligand-activated transcription factor that mediates estrogen actions in target tissues. Several common polymorphisms of the ER-alpha gene have been reported to be associated with alterations in receptor expression and function. We evaluated the hypothesis that genetic polymorphisms in the ER-alpha gene may be associated with breast cancer risk in a population-based c...

Journal: :The Journal of biological chemistry 2005
Timothy V Beischlag Gary H Perdew

The aryl hydrocarbon receptor (AHR) and the aryl hydrocarbon receptor nuclear translocator (ARNT) form a heterodimeric transcription factor upon binding a wide variety of environmental pollutants, including 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD). AHR target gene activation can be repressed by estrogen and estrogen-like compounds. In this study, we demonstrate that a significant component of...

Journal: :The Journal of biological chemistry 1993
S Weng R G Spiro

A novel alpha-mannosidase has been identified in rat liver endoplasmic reticulum (ER) which at neutral pH processes the Man9GlcNAc oligosaccharide of glycoproteins by specifically cleaving the terminal mannose residue of the alpha 1,6-linked chain to yield Man8GlcNAc, isomer C. This enzyme accounted for about half of the total ER alpha-mannosidase activity and was fully active at the concentrat...

2010
Tomasz Kotwicki Blazej Rusin Aleksandra Glodek Anna Jankowska Malgorzata Kotwicka

Introduction Estrogens can influence skeletal muscles activity by stimulating angioand muscle-genesis. These hormones act through specific alpha and beta estrogen receptors (ER). Muscular tissue may be a target for estrogens, however there is no data on ER expression in paravertebral muscles in patients with idiopathic scoliosis (IS). During early adolescence the increase of estrogen serum leve...

Journal: :The Journal of Cell Biology 1989
D W Andrews L Lauffer P Walter V R Lingappa

The signal recognition particle (SRP) and SRP receptor act sequentially to target nascent secretory proteins to the membrane of the ER. The SRP receptor consists of two subunits, SR alpha and SR beta, both tightly associated with the ER membrane. To examine the biogenesis of the SRP receptor we have developed a cell-free assay system that reconstitutes SR alpha membrane assembly and permits bot...

Journal: :The Journal of endocrinology 2009
Rusana Simonoska Annika E Stenberg Maoli Duan Konstantin Yakimchuk Anders Fridberger Lena Sahlin Jan-Ake Gustafsson Malou Hultcrantz

There are well known differences between males and females in hearing. In the present study, the role of estrogen receptor-beta (ER-beta; listed as ESR2 in the MGI Database) in hearing was investigated by comparing hearing and morphology of the inner ear in ER-beta knock-out mice (ER-beta(-/-)) with that of wild-type (WT) littermates. Hearing was analyzed with auditory brainstem response audiom...

Journal: :Acta pharmacologica Sinica 2003
Guo-Fang Lin Qing-Wen Ma Dong-Sheng Zhang Yong-Lin Zha Ke-Jian Lou Jian-Hua Shen

AIM To explore the possible association of different polymorphic forms of human alpha-estrogen receptor (ER-alpha) and aryl hydrocarbon receptor gene (Ahr) with the risk to senile dementia in farmers in Shanghai suburb. METHODS Senile dementia patients (n=52) were examined for ER-alpha and Ahr gene polymorphism genotyping. Healthy individuals (n=125) in the same area were selected as a commun...

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