Abstract We show optimal bounds of the form $$Q_\alpha<M<Q_\beta $$ Q α < M β , where $$\begin{aligned} Q_\alpha (x,y)={\mathsf {A}}(x,y)\frac{{\mathsf {A}}^2(x,y)}{(1-\alpha ){\mathsf {A...

Here, antitumor mechanism of cinnamaldehyde derivative CB-PIC was elucidated in human SW620 colon cancer cells. CB-PIC significantly exerted cytotoxicity, increased sub-G1 accumulation, and cleaved PARP with apoptotic features, while it enhanced the phosphorylation of AMPK alpha and ACC as well as activated the ERK in hypoxic SW620 cells. Furthermore, CB-PIC suppressed the expression of HIF1 al...

Objective Background: Failure in the endometrial receptivity may account for a significant number of infertility cases including unexplained infertility in women. Reduction in the endometrial estrogen receptor-alpha (ER-α) expression during window of implantation may be a critical event that coincides with expression of specific genes and providing a receptive endometrium. The aim of present st...

Black-box alpha (BB-α) is a new approximate inference method based on the minimization of α-divergences. BB-α scales to large datasets because it can be implemented using stochastic gradient descent. BB-α can be applied to complex probabilistic models with little effort since it only requires as input the likelihood function and its gradients. These gradients can be easily obtained using automa...

Abnormal alpha-synuclein (α-synuclein) expression and aggregation is a key characteristic of Parkinson's disease (PD). However, the exact mechanism(s) linking α-synuclein to the other central feature of PD, dopaminergic neuron loss, remains unclear. Therefore, improved cell and in vivo models are needed to investigate the role of α-synuclein in dopaminergic neuron loss. MicroRNA-7 (miR-7) regul...

Alpha-1-antitrypsin is the most abundant circulating protease inhibitor. It is mainly produced by the liver and secreted into the circulation where it acts to prevent excessive proteolytic damage in the lungs by the enzyme neutrophil elastase. The most common severe deficiency allele is the Z mutation, which causes the protein to self-associate into ordered polymers. These polymers accumulate w...

By Aguglia et al., new quasi-Hermitian varieties ℳ α , β ${{\rm{ {\mathcal M} }}}_{\alpha ,\beta }$ in PG ( r q 2 ) $\text{PG}(r,{q}^{2})$ depending on a pair of parameters $\alpha $ from the underlying field GF $\text{GF}({q}^{2})$ have been constructed. In present paper we study structure lines contained and consequently determine projective equivalence classes such for $q$ odd = 3 $r=3$ . As...

Introduction:The aim of this study was to investigate the effect of fasting in Ramadan on visfatin, tumor necrosis factor alpha (TNF-α) and adiponectin level in human. Methods:Thirty four men aged 24 to 55 years old were selected from those people who were willing to fast in Ramadan. The blood sample was obtained from each participant in fasting state at the beginning and the end of study to d...

BACKGROUND It is well established that the Mediterranean and Arab populations are at high risk for thalassemias in general and for alpha-thalassemia in particular. Yet, reports on alpha-thalassemia in Lebanon are still lacking. In this study, we aim at assessing the incidence of alpha-thalassemia in the Lebanese population. METHODS 230 newborns' dried blood cards remaining from routine neonat...

Katznelson’s Question is a long-standing open question concerning recurrence in topological dynamics with strong historical and mathematical ties to problems combinatorics harmonic analysis. In this article, we give positive answer for certain towers of skew-product extensions equicontinuous systems, including systems the form <mml:math xmlns:mml="htt...