The appropriateness of relying on the coefficient of determination (r) as a statistical metric for judging the predictability of human clearance (CL) based on interspecies animal data was assessed. An explicit mathematical expression was derived for r as a function of species body weight and the corresponding measured value of CL. The derived mathematical function demonstrated that r is numeric...

LINKED ARTICLES This article is commented on in the editorial by Holford NHG and Anderson BJ. Why standards are useful for predicting doses. Br J Clin Pharmacol 2017; 83: 685-7. doi: 10.1111/bcp.13230 AIM: When different models for weight and age are used in paediatric pharmacokinetic studies it is difficult to compare parameters between studies or perform model-based meta-analyses. This study ...

Historically, allometric equations relate organismal traits, such as metabolic rate, individual growth rate, and lifespan, to body mass. Similarly, Boltzmann or Q(10) factors are used to relate many organismal traits to body temperature. Allometric equations and Boltzmann factors are being applied increasingly to higher levels of biological organization in an attempt to describe aggregate prope...

Allometric scaling on the basis of bodyweight raised to the power of 0.75 (AS0.75) is frequently used to scale size-related changes in plasma clearance (CLp) from adults to children. A systematic assessment of its applicability is undertaken for scenarios considering size-related changes with and without maturation processes. A physiologically-based pharmacokinetic (PBPK) simulation workflow wa...

In multivariate regression, interest lies on how the response vector depends a set of covariates. A regression model is proposed where covariates explain variation in only direction first principal component axis. This not parsimonious, but it provides an easy interpretation allometric growth studies log-transformed data corresponds to constants growth. The naturally generalizes two–group exten...

BACKGROUND Chemical restraint is of great importance in the clinical practice of wildlife animals. In such, interspecific allometric scaling proposes pharmacological doses to a wide range of species, based on previously known doses for domestic animals and the target animal's body mass. The objective was to compare chemical restraint responses in the greater rhea (Rhea americana) with conventio...

Abstract Scomberoides commersonnianus is one of the commercially important fishes of the family Carangidae. In this study, 563 specimens (292 males, 247 females, and 24 sexually unknown ones) were collected from the north-west of the Persian Gulf. Length-weight relationships and condition factors were determined for each sex in four length classes within different seasons. In general, the growt...