The success of hematopoietic stem cell transplantation (HSCT) lies with the ability of the engrafting immune system to remove residual leukemia cells via a graft-versus-leukemia effect (GvL), caused either spontaneously post-HSCT or via donor lymphocyte infusion. GvL effects can also be initiated by allogenic mismatched natural killer cells, antigen-specific T cells, and activated dendritic cel...

The eyes of 62 patients who had received allogenic renal transplants were examined for eye disease. Thirty-six patients were found to have steroid induced cataract. Six patients had ocular hypertension. Twelve patients showed arteriosclerotic changes in their fundi relating to their previous hypertensin. There was no significant difference in HLA type in patients who developed cataract and thos...

Over the years, the different scientific societies have established a series of recommendations on antifungal prophylaxis based on prospective studies performed with different drugs1-6. Table 1 summarises these recommendations for the three situations in which fungal infection is most frequent: acute leukaemias, myelodysplastic syndromes and autologous and allogenic hematopoietic stem cell tran...

The authors report the case of a chronic myeloid leukemia (CML) patient submitted to allogenic bone marrow transplantation, who had probably never entered complete remission. The disease was reactivated as a granulocytic sarcoma, next to a platinum plate installed to correct a tibia fracture 11 years earlier. Its final event was a myeloid Ph1 + blastic crisis that was unsuccessfully treated wit...

Introduction . Infections are among the most common complications after allogeneic hematopoietic stem cell transplantation. Aim — to provide a literature review on main characteristics of infectious allogenic transplantation and risk factors for their development. Main findings Apart from direct such as neutropenia, hypogammaglobulinemia, lymphopenia, there indirect transplant-related condition...

background mandibular continuity defects occur after tumor resection, maxillofacial injury, or osteomyelitis. despite the current availability of a plethora of treatment modalities, bone substitutes, and various clinical adjuncts, an exact reconstructive recapitulation of large bony defects continues to be beyond reach. in this clinical pilot study, we report a novel method for reconstruction o...