Kounis syndrome is an acute coronary syndrome concurrently occurs with allergic or hypersensitivity reactions. In patient with this syndrome, inflammatory mediators released due to an allergic reaction implicate to induce coronary artery spasm and atheromatous plaque rupture. We describe a patient with coronary artery disease who developed acute perioperative myocardial infarction leading to ca...

Allergic reactions to the ubiquitous pathogenic and non-pathogenic fungi are models for the study of hypersensitivity. Emphasis will be placed wherever possible in this paper on findings in man, in whom fungal hypersensitivity is widely prevalent. These findings throw light upon fungal antigens in relation to clinical manifestations and upon the nature and mechanism of allergic reactions. It is...

Penicillin is the drug that most often leads to allergic reactions and anaphylaxis. The incidence of adverse events triggered by penicillins is believed to be between 1% and 10%. Up to one-tenth of these episodes are life-threatening, with the most serious reactions occurring in patients with no history of allergy. The case of a 5 year, 3 month-old female who had a severe allergic reaction to a...

After their activation, mast cells release a variety of bioactive mediators that contribute to characteristic symptoms of allergic reactions. Ex vivo analysis of mast cells derived from their progenitors or isolated from mice is an indispensable tool for the development of newer and more effective therapies of allergic syndromes. Here, we describe the differentiation and isolation of mouse mast...