نتایج جستجو برای: allergic airway inflammation

تعداد نتایج: 272736  

2010
Nisebita Sahu J. Luis Morales Deborah Fowell Avery August

Murine models of allergic asthma have been used to understand the mechanisms of development and pathology in this disease. In addition, knockout mice have contributed significantly to our understanding of the roles of specific molecules and cytokines in these models. However, results can vary significantly depending on the mouse strain used in the model, and in particularly in understanding the...

2015
Eva Kovacova Silvia Gavliakova Tomas Buday Jana Plevkova

Background Upper airway diseases (e.g. allergic rhinitis (AR)) are one of most common causes of chronic cough in subjects with negative X-ray finding. In UACS (upper airway cough syndrome), cough is strongly associated with the ongoing nasal inflammation. Effective treatment of nasal inflammation may lead to down regulation of pathologically enhanced chronic cough. Histamine plays a critical ro...

Journal: :Current allergy and asthma reports 2011
Tania Maes Kurt G Tournoy Guy F Joos

Airway diseases such as allergic asthma and rhinitis are characterized by a T-helper type 2 (Th2) response. Treatment of allergic airway diseases is currently limited to drugs that relieve disease symptoms and inflammation. In the search for new therapeutics, efforts have been made to treat allergic airway disease with gene therapy, and many preclinical studies have demonstrated its impressive ...

Journal: :PLoS ONE 2008
Alba Llop-Guevara Marc Colangelo Derek K. Chu Cheryl Lynn Moore Nicole A. Stieber Tina D. Walker Susanna Goncharova Anthony J. Coyle Lennart K. A. Lundblad Paul M. O'Byrne Miroslav Lovric Manel Jordana

BACKGROUND Allergic asthma is a complex process arising out of the interaction between the immune system and aeroallergens. Yet, the relationship between aeroallergen exposure, allergic sensitization and disease remains unclear. This knowledge is essential to gain further insight into the origin and evolution of allergic diseases. The objective of this research is to develop a computational vie...

Journal: :Journal of immunology 2007
Peter R Hoffmann Claude Jourdan-Le Saux Fukun W Hoffmann Peter S Chang Oana Bollt Qingping He Elizabeth K Tam Marla J Berry

Asthma is driven by allergic airway inflammation and involves increased levels of oxidative stress. This has led to speculation that antioxidants like selenium (Se) may play important roles in preventing or treating asthma. We fed diets containing low (0.08 parts per million), medium (0.25 parts per million), or high (2.7 parts per million) Se to female C57BL/6 mice and used an established OVA ...

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