The use of light to facilitate copper-catalyzed cross-couplings of nitrogen nucleophiles can enable C-N bond formation to occur under unusually mild conditions. In this study, we substantially expand the scope of such processes, establishing that this approach is not limited to reactions of carbazoles with iodobenzene and alkyl halides. Specifically, we demonstrate for the first time that other...

We review some applications of copper derivatives as synthetic tools: stoichiometric organocopper reagents and organomagnesium derivatives in the presence of catalytic amounts of copper salts are able to give a regioselective addition on to acetylenic substrates and to alkylate alkyl or vinyl halides, bromohydrines, their tosylates and carboxylates, and a large variety of allylic substrates. IN...

Available online-1-n-butyl-3-methylimidazolium selenocyanate ([bmim][SeCN]) proved to be a very efficient reagent for selenocyanation of alkyl halides. As part an eco-friendly process, no organic solvents were used during the transformation and reaction times are reduced by using microwave as heating source. The ionic liquid was carefully recycled in two different ways. Selenocyanate compounds ...

In the current work, aromatic amines and alkyl halides have been converted to corresponding azides 2a‒d 4a-d by reaction with sodium nitrite azide respectively for halides. Then, dipropargyl ether derivative of D-mannose 8 has synthesized from diacetone mannose that obtained treatment (5) dry acetone in presence sulfuric acid. aldol condensation used prepare diol 7 diacetonide 6. The compound p...

ÐTitanocene(III) chloride and zirconcene(III) chloride are effective and mild reagents for radical generation in organic synthesis. In carbohydrate chemistry, these species are useful for the conversion of glycosyl halides to glycals, and for the stereospeci®c preparation of C-glycosides. In all cases, the 1-glycosyl radical is an active intermediate, generated by reaction of carbohydrate subst...

Ab initio calculations using the 6-311G**, cc-pVDZ, and (valence) double-zeta pseudopotential (DZP) basis sets, with (MP2, QCISD, CCSD(T)) and without (HF) the inclusion of electron correlation, and density functional (BHandHLYP, B3LYP) calculations predict that the transition states for the reaction of acetyl radical with several alkyl halides adopt an almost collinear arrangement of attacking...

We describe here the conjugate addition of tert-butyllithium to vinyl systems boronic esters generate a borata-alkene intermediate, followed by sequential SN2 reaction with alkyl halides, at room temperature. envisioned this goal through engaged C(sp3) chemical entities avoiding metal catalysts, additives, radical initiators or specific irradiation. This guarantees that new tetrasubstituted car...

Alkyl bromides and chlorides can be reduced to the corresponding hydrocarbons utilizing zinc in the presence of an amine additive. The process takes place in water at ambient temperatures, enabled by a commercially available designer surfactant. The reaction medium can be readily recycled, and the amount of organic solvent invested for product isolation is minimal, leading to very low E Factors.

A new synthetic pathway to various mono-alkyl-substituted phosphinoboranes HRP–BH2–NMe3 has been developed. The route starting from alkyl halides and NaPH2 followed by metalation salt metathesis is performed in a one-pot procedure leads higher yields purity of the resulting phosphinoboranes, as compared previously reported routes. Additionally, scope accessible compounds could be expanded short...