A bioactivity guided study of a cf. Caldora penicillata species, collected during a 2013 expedition to the Pacific island of Saipan, Northern Mariana Islands (a commonwealth of the USA), led to the isolation of a new thiazoline-containing alkaloid, laucysteinamide A (1). Laucysteinamide A is a new monomeric analogue of the marine cyanobacterial metabolite, somocystinamide A (2), a disulfide-bon...

To overcome multidrug resistance (MDR) in cancer chemotherapy, we prepared various plant extracts and searched for a component which is effective for inhibition of MDR. MDR inhibition activity was determined by measuring cytotoxicity to MDR cells using multidrug resistant human fibrocarcinoma KB V20C, which is resistant to 20 nM vincristine and expresses high level of mdr1 gene. Of various plan...

The antiplasmodial activity of crude ethanol extract of Vernonia amygdalina leaf in Plasmodium berghei infected mice was evaluated. A total of 20 mice were randomly distributed into five groups of four mice each. The infected mice were treated immediately after inoculation with 200, 400 and 600mg/kgbw of the extract respectively. Group 4 (Positive control) was treated with standard drug (Chloro...

The genotoxicity of the ethanolic extract betel nut was evaluated using sarcoma 180 tumour bearing mouse considering sperm motility, viability, biochemical estimation fructose in seminal fluid and head morphology assays. Sperm studied by H-E staining Toluidine blue method. But method is a reliable to evaluate DNA damage sperms. Ethanolic BNE (betel extract) can suppress percentage viability lev...

Aspernigerin (1), a novel cytotoxic alkaloid consisting of an unprecedented structural framework has been isolated from the extract of a culture of Aspergillus niger IFB-E003, an endophyte in Cyndon dactylon. Its structure was elucidated on the basis of comprehensive NMR spectral analysis and confirmed by single-crystal X-ray analysis. Aspernigerin (1) has been shown to be cytotoxic to the tumo...

In recent years, a number of novel 3-alkyl pyridinium alkaloids were identified from the crude extract of the Arctic marine sponge Haliclona viscosa [1 – 5]. The material available from this sponge was limited by the small size of the individuals, their slow growth rate and the effort to sample substainably in the Arctic ecosystem. A new refinement of the spectroscopic methods led to improved r...

Incarvillea sinensis is a wild plant distributed in northern China. The dried whole plant has been traditionally used to treat rheumatism and relieve pain as an ancient Chinese crude drug. To investigate its antinociceptive activity, we evaluated several fractions derived from the methanolic extract of Incarvillea sinensis in the formalin-induced pain model in mice. Incarvillateine, a novel mon...

Skin Fruit Banana goods (Musa acuminate Colla) can used as ingredient blocker bacteria. Research this aim for knowing activity antibacterial preparation ointment from extract skin fruit banana colla) against Staphylococcus aureus. Method Study conducted Experimental, obtained with use method maceration solvent 96% followed after that the was concentrated rotary evaporator. Ethanol tested Phytoc...

Chemical investigation of Croton pullei (Euphorbiaceae) collected in the Brazilian Amazon region was revisited. The chemical composition of the essential oils of leaves and stems was analyzed by GC/MS. It was found that both the oils comprise mainly terpenes, among which linalool was the major one (24.90 and 39.72%, respectively). Phytochemical investigation of the stem methanol extract led to ...