This study examines the relationships between inflammation, surfactant protein (SP) expression, surfactant function, and lung physiology in a murine model of acute lung injury (ALI). 129/J mice received aerosolized endotoxin lipopolysaccharide [LPS] daily for up to 96 h to simulate the cytokine release and acute inflammation of ALI. Lung elastance (E(L)) and resistance, lavage fluid cell counts...

Transendothelial hyperpermeability caused by numerous agonists is dependent on heat shock protein 90 (Hsp90) and leads to endothelial barrier dysfunction (EBD). Inhibition of Hsp90 protects and restores transendothelial permeability. Hyperacetylation of Hsp90, as by inhibitors of histone deacetylase (HDAC), suppresses its chaperone function and mimics the effects of Hsp90 inhibitors. In this st...

Loss of lung-fluid homeostasis is the hallmark of acute lung injury (ALI). Association of catenins and actin cytoskeleton with vascular endothelial (VE)-cadherin is generally considered the main mechanism for stabilizing adherens junctions (AJs), thereby preventing disruption of lung vascular barrier function. The present study identifies endothelial focal adhesion kinase (FAK), a nonreceptor t...

traditions and manners of nuba is part of egyptian’s culture which is emerged in novelists’ works of nuba in various ways and most of the times they have been denied and objected; because ignorance and prejudice govern them, is routed in their culture and except in very few cases, they never change. the novel “playing over nuba mountains” by edris ali is one of the novels which is clearly analy...

INTRODUCTION The function of the vascular endothelial growth factor (VEGF) system in acute lung injury (ALI) is controversial. We hypothesized that the role of VEGF in ALI may depend upon the stages of pathogenesis of ALI. METHODS To determine the responses of VEGF and its receptors during the early onset of ALI, C57BL6 mice were subjected to intestinal ischemia or sham operation for 30 minut...

OBJECTIVES Human airway epithelial cells are the principal target of human rhinovirus (HRV), a common cold pathogen that triggers the majority of asthma exacerbations. The objectives of this study were 1) to evaluate an in vitro air liquid interface cultured human airway epithelial cell model for HRV infection, and 2) to identify gene expression patterns associated with asthma intrinsically and...

You have accessJournal of UrologyProstate Cancer: Basic Research & Pathophysiology I (MP33)1 Sep 2021MP33-10 IDENTIFYING THE MECHANISTIC CONNECTION BETWEEN INFLAMMATORY BOWEL DISEASE AND PROSTATE CANCER: A LARGE-SCALE GENE EXPRESSION ANALYSIS Adam Weiner, Travis Meyers, Erin Gilbertson, Linda Kachuri, Tamara Lotan, Edward Schaeffer, Conor Driscoll, Kaitlyn O'Shea, Christopher Yang, Jordan Rich,...

Broad research interests and related applications: My research is in the area of stochastic systems, computational methods for sensing, estimation, and control problems, with a focus on robotic systems. In real-world systems, uncertainty (both in the system model and sensory readings) is omnipresent. A few of the vast set of applications for this research include (i) Motion planning for mobile ...

BACKGROUND It is important to study the factors affecting the clinical mortality of the severe multiple trauma population. The present study was aimed to identify the potential risk factors that could affect mortality rate of acute lung injury (ALI) in severely injured multiple trauma population and to investigate the effects of certain risk factors on the prognosis of different patient subpopu...