Abstract The chlorinated natural products, rubrolides B, I, K, L, M and O analogues were synthesized in only five steps employing a robust divergent synthetic strategy. synthesis is performed without using protecting groups starting from key intermediate, which can be commercially available tetronic acid two steps. Selective halogenation vinylogous aldol condensation enable the efficient of hig...

Chalcones are the primary building blocks for flavonoids and isoflavonoids production. a three-carbon, -unsaturated carbonyl system. form when an aromatic aldehyde reacts with acetophenones in presence of catalyst. For synthesis these molecules, variety methods approaches have been reported. The Aldol condensation Claisen-Schmidt reactions most commonly referenced synthetic protocols literature...

A new and efficient method has been developed for the synthesis of 4-aryl-7-benzylidene-1,3,4,5,6,7-hexahydro-2H-cyclopenta[d]pyrimidin-2-ones through Biginelli-like reaction of cyclopentanone, with urea/thiourea and aromatic aldehyde employing p-dodecylbenzenesulfonic acid (DBSA) as a recyclable catalyst under solvent-free condition. The recovered catalyst was recycled for further runs. The pr...