Identifying the biological substrates of complex neurobehavioral traits such as alcohol dependency pose a tremendous challenge given the diverse model systems and phenotypic assessments used. To address this problem we have developed a platform for integrated analysis of high-throughput or genome-wide functional genomics studies. A wealth of such data exists, but it is often found in disparate,...

The purpose of this article was to present a review of the effects of alcohol consumption by pregnant mothers on their newborn. Definitions, prevalence, pathophysiology, clinical features, diagnostic criteria, follow-up, treatment and prevention were discussed. A search was performed in Medline, LILACS, and SciELO databases using the following terms: "fetus", "newborn", "pregnant woman", "alcoh...

Background and aims Problem and pathological gambling have been associated with elevated rates of both Axis-I and Axis-II psychiatric disorders. Although both problem gambling and psychiatric disorders have been reported as being more prevalent among lower income vs. middle/higher income groups, how income might moderate the relationship between problem-gambling severity and psychopathology is ...

background: a good proportion of poisoned patients treated at poisoning wards are elderly. this study was designed to evaluate the epidemiologic pattern of acute poisoning in elderly in hamadan, western iran. methods: in this retrospective cross-sectional study, poisoned patients aged 60 years and older treated at department of poisoning of farshchian hospital from march 2008 to march 2013 were...

background due to the chronic and recurrent nature of addiction, many people who quit drug addiction may slip back into the pattern of using drugs shortly after the detoxification period. emotion-regulation strategies and resilience play an important role in preventing the recurrences of substance abuse. objectives this study aimed to compare the effects of methadone-maintenance therapy (mmt) a...

conclusions the length of sensory and motor blockade is shorter in chronic opioid abusers. adding 10 µg sufentanil to hyperbaric bupivacaine in opium abusers lengthened the sensory and motor block duration. results the duration of sensory and motor block were significantly less in group c (537.0 ± 40.1 minutes, 479.0 ± 34.8 minutes) and the longest duration of sensory and motor block was observ...

background according to recent theories on addiction, attentional bias towards drug-related stimuli plays a pivotal role in the initiation of drug abuse. objectives the present study attempted to investigate attentional bias towards drug-related words in addicts and non-addicts. patients and methods to attain the objectives, following a causal-comparative study, a number of 15 addicts under tre...

Alcohol dependence (alcoholism) is a complex disorder attributed to the interaction of genetic and environmental factors that form a collage of "disease" predisposition, which is not identical for every alcohol-dependent individual. There is considerable evidence to demonstrate that genetic predisposition accounts for roughly half the risk in the development of alcohol dependence. Both family a...