OBJECTIVE Current debates on the bronchodilator response in COPD patients and whether the variation in FEV1 can be considered as an indicator of complete reversibility in such patients motivated us to conduct this study. The objective of the study was to determine the effect of albuterol on the resistive and reactive properties of the respiratory system in COPD patients. METHODS We evaluated ...

BACKGROUND Symptoms of asthma commonly increase at night for a variety of reasons. While different options are available for the management of nocturnal asthma, theophylline has maintained a prominent role in treating this problem, and it is widely promoted as a first-line agent. Very recent reports stress the use of anti-inflammatory agents as the drugs of choice for the long-term treatment of...

Drug administration via high flow nasal cannula (HFNC) has been described in pediatrics but the amount of albuterol delivery with an HFNC is not known. The purpose of this study is to quantify aerosol delivery with heliox and oxygen (O(2)) in a model of pediatric ventilation. A vibrating mesh nebulizer (Aeroneb Solo, Aerogen) was placed on the inspiratory inlet of a heated humidifier and heated...

Over the past 12 years there have been 12 randomised control trials, involving 843 infants, evaluating the effect of salbutamol or albuterol on bronchiolitis. Of these, nine (75%) showed that bronchodilators had no effect. In three studies a small transient improvement in the acute clinical score was seen. Ipratropium bromide had no significant effect. There have been five recent randomised tri...

To the Editor: Wechsler et al. (July 14 issue)1 describe self-reported outcomes of albuterol treatment as compared with placebo in patients with mild-to-moderate asthma. One possible explanation for the lack of incremental benefit with respect to these outcomes may be related to the experimental design of the study. The benefit of the bronchodilator effect of albuterol could have not been appre...

RE, Kliegman RM, Jenson HB, eds. Nelson Textbook of Pediatrics. 17th Edn. Philadelphia, Saunders, 2003; pp. 994–999. 8 American Academy of Pediatrics Subcommittee on Diagnosis and Management of Bronchiolitis, Diagnosis and management of bronchiolitis. Pediatrics 2006; 118: 1774–1793. 9 Klassen TP, Rowe PC, Sutcliffe T, Ropp LJ, McDowell IW, Li MM. Randomized trial of salbutamol in acute bonchio...