The relative contribution of, and possible mechanism of interaction between, aflatoxin and hepatitis B virus (HBV) in the development of primary hepatocellular carcinoma can be better investigated now that markers of individual exposure to both factors are available. In this study, blood samples were collected over a 1 -month period from 1 1 7 children aged 3 to 4 years, resident in Kuntair or ...

BACKGROUND AND AIMS Chronic hepatitis C is a slowly progressive disease and eventually causes hepatocellular carcinoma in many patients. Although interferon (IFN) therapy has been used for viral eradication, its success rate is only about 30%. In patients in whom it has failed (non-responders), there are several patterns of serum alanine aminotransferase (ALT) values, and detection of serum HCV...

OBJECTIVE Type 2 diabetes adversely affects the liver and kidney function tests. This study was conducted to determine that either the liver and kidney functions are disturbed in the patients having gestational diabetes mellitus (GDM). METHODS One hundred and three women with GDM, and 97 healthy pregnant women (HPW) in their third trimester were registered in the Obs/Gyn Unit of Khyber Teachi...

BACKGROUND Hepatitis B virus (HBV) infection remains a severe public health problem. Investigating its prevalence and trends is essential to prevention. METHODS To evaluate the effectiveness of HBV vaccination under the 1992 Intervention Program for infants and predicted HBV prevalence trends under the 2011 Program for all ages. We conducted a community-based investigation of 761,544 resident...

Epigallocatechin gallate (EGCG) is the principle antioxidant of the green tea extract. The effect of EGCG was studied against the hepatotoxicity induced by N-nitrosodiethylamine (NDEA) in rats. The male rats were exposed to NDEA (0.1 mg/ ml) dissolved in drinking water separately and along with 5, 10 and 15 mg/ml of EGCG for 21 days. The activity of serum aspartate amino transferase (AST), seru...

Objectives: To contribute to case management algorithms and guidelines by evaluating the clinical symptoms, laboratory data, risk factors mortality rates of patients admitted health institutions with tick bite in Tokat. 
 Methods: The virus determination was made from blood conventional PCR 141 patient. Epidemiological data such as socio-demographic variables were compared biochemical hema...

UDP-glucuronosyltransferases (UGTs) are phase II drug-metabolizing enzymes that catalyze glucuronidation of various drugs. Although experimental rodents are used in preclinical studies to predict glucuronidation and toxicity of drugs in humans, species differences in glucuronidation and drug-induced toxicity have been reported. Humanized UGT1 mice in which the original Ugt1 locus was disrupted ...

Serum ferritin concentrations have been measured in 124 patients with homozygous beta thalassaemia who were between 2 and 21 years old, had received 11--504 units of blood but had not undergone splenectomy. There were highly significant correlations between serum ferritin concentration and both the amount of blood transfused and alanine amino-transferase (ALT) activity. However, multivariate an...

AIM To investigate the dynamic alteration of mitochondrial carnitine palmitoyl transferase II (CPT-II) expression during malignant transformation of rat hepatocytes. METHODS Sprague-Dawley male rats were fed with normal, high fat (HF), and HF containing 2-fluorenylacetamide (2-FAA) diet, respectively. According to the Hematoxylin and Eosin staining of livers, rats were divided into control, f...