Alcoholic and nonalcoholic liver steatosis have an indistinguishable spectrum of histological features and liver enzyme elevations. In this study, we investigated the potential of the ethanolic extract of Acanthopanax koreanum Nakai (AK) to protect against experimental alcoholic liver disease in a mouse model that couples diet and daily ethanol bolus gavage. Fifty-six C57BL/6J mice were randoml...

Organ transplant recipient (OTR) subjects are at high risk of skin cancer such as squamous cell carcinoma and basal cell carcinoma. Actinic keratosis (AK) is considered the precursor of these non-melanoma skin cancers. Sun protection is mandatory in subjects with AK and this preventive strategy is very important in OTR. Treatment of the field of cancerization is also crucial to reduce the risk ...

BACKGROUND/PURPOSES Monascin (MS) and ankaflavin (AK) produced by Monascus purpureus NTU 568 were proven to show excellent hypolipidemic effects in our previous studies; however, the mechanism is still unclear. METHODS This study used MS, AK, and monacolin K as test substances and performed tests on rats fed high-fat and high-cholesterol diet for 8 weeks. The lipid levels and the related prot...

Let J be a Jacobi matrix with elements bk on the main diagonal and elements ak on the auxiliary ones. We suppose that J is a compact perturbation of the free Jacobi matrix. In this case the essential spectrum of J coincides with [−2, 2], and its discrete spectrum is a union of two sequences {xj }, x + j > 2, x − j < −2, tending to ±2. We denote sequences {ak+1 − ak} and {ak+1 + ak−1 − 2ak} by ∂...

Cutaneous squamous cell carcinoma (cSCC) is the second most common skin cancer and usually progresses from a UV-induced precancerous lesion termed actinic keratosis (AK). Despite various efforts to characterize these lesions molecularly, the etiology of AK and its progression to cSCC remain partially understood. Here, we use Infinium MethylationEPIC BeadChips to interrogate the DNA methylation ...

Data are presented demonstrating that adenylate kinase (AK; EC 2.7.4.3) is an oncodevelopmentalenzyme in the prostate of Copenhagen rats. We selected the Dunning tumor (dorsal rat prostate) as a model system because it most nearly approximatesthe human pathology.Four sublines of the tumor (R3327-H, R3327-AT, MAT Lu, and MAT LyLu)were studied.The tumor sublineswere maintainedas solid tumors in s...

Actinic keratosis (AK) negatively influences patient quality of life as measured by the disease-specific Actinic Keratosis Quality of Life (AKQoL) questionnaire. The quality of life in Australian patients was significantly less affected than in Danish patients. We hypothesize that general factors such as public awareness and cultural connotations of AK, may influence the impact of AK on quality...

Infrared photometry and spectroscopy (1-25 μm) of background stars reddened by the Lupus molecular cloud complex are used to determine the properties of the grains and the composition of the ices before they are incorporated into circumstellar envelopes and disks. H2O ices form at extinctions of AK = 0.25 ± 0.07 mag (AV = 2.1 ± 0.6). Such a low ice formation threshold is consistent with the abs...

Recently Dalal and Govil [5] proved that, for any set of positive numbers {Ak}k=1 such that ∑n k=1 Ak = 1, a complex polynomial P (z) = ∑n k=0 dkz k (dk = 0, 0 ≤ k ≤ n) has all its zeros in the annulus A = {z : r1 ≤ |z| ≤ r2}, where r1 = min 1≤k≤n { Ak ∣∣∣d0 dk ∣∣∣ } 1 k and r2 = max 1≤k≤n { 1 Ak ∣∣∣dn−k dn ∣∣∣ } 1 k . This paper presents the best possible results in the same direction by ident...

Solid organ transplant recipients are predisposed to actinic keratoses (AK) and nonmelanoma skin cancers, owing to the lifelong immunosuppression required. Today, increasing numbers of organ transplants are being performed and organ transplant recipients (OTRs) are surviving much longer. Photodynamic therapy (PDT) is proving a highly effective treatment modality for AK amongst this susceptible ...