Leucocyte-endothelial adhesion molecules are involved in the initial stages of the recruitment and migration of inflammatory leucocytes from the circulation to sites of inflammation. There is accumulating evidence for their involvement in the pathophysiology of airway mucosal allergic inflammation, such as that found in asthma and rhinitis. The best characterized adhesion molecule families are ...

Asthma and chronic obstructive pulmonary disease (COPD) are two prevalent chronic airway diseases that have a high personal and social impact. They likely represent a continuum of different diseases that may share biological mechanisms (i.e. endotypes), and present similar clinical, functional, imaging and/or biological features that can be observed (i.e. phenotypes) which require individualise...

Foreign bodies in upper airway may have various presentations and be life threatening. Leeches can attach to upper airway and cause serious problems. Herein we report a 55-year-old man with hemoptysis due to attachment of leech and explain our technique for its removal.

Patients with Morquio syndrome possess a number of characteristics which may complicate an anaesthetic procedure. The most important is that a deposition of mucopolysaccharides in the soft tissues of the oro-pharynx distorts the airway, making the airway management difficult, while the atlanto-axial instability puts these patients at risk of subluxation and quadriparesis. As the endotracheal in...

Airway management in a polytraumatized patient with severe spinal and thoracic deformities demands detailed investigation of anatomical characteristics of the head, neck and airways, as well as thoracic configuration, before attempting endotracheal intubation. This enables the physician to predict a difficult airway and prepare for difficult airway management. We present a case of a 50-year-old...

Cystic fibrosis (CF) is a recessive inherited disease associated with multiorgan damage that compromises epithelial and inflammatory cell function. Induced pluripotent stem cells (iPSCs) have significantly advanced the potential of developing a personalized cell-based therapy for diseases like CF by generating patient-specific stem cells that can be differentiated into cells that repair tissues...

Pierre Robin sequence (PRS) is characterized by the triad micrognathia, glossoptosis, and airway obstruction, commonly associated with cleft palate. This study reports the case of a patient with characteristics consistent with the diagnosis of PRS in the 1st week of life. To stabilize the airway, oro-tracheal intubation was performed without success, followed by tracheostomy and glossopexy and ...

mucormycosis is a serious fungal infection caused by the filamentous fungi of the mucorales order of the class of zygomycetes. mucormycosis is classically defined as an opportunistic fatal infection. in this report we explain a 49 years old woman with palato-orbital tract as a sequel of rhino cerebral mucormycosis and end stage renal disease candidate for kidney transplantation. difficulties in...