We present the results of a dynamical analysis of three rich, X-ray luminous galaxy clusters, Abell 222, Abell 223 and Abell 520, that are at intermediate redshifts. Our study is based on radial velocities for 71 cluster members, respectively 30 for A 222, 20 for A 223 and 21 for A 520, measured from spectra obtained at the Canada-France-Hawaii Telescope, the European Southern Observatory, and ...

Metastatic castration-resistant prostate cancer (mCRPC) frequently metastasizes to the bone, often resulting in painful skeletal events, reduced quality of life, and reduced survival. The beta-emitting radiopharmaceuticals strontium-89 and samarium-153 alleviated pain in mCRPC patients with widespread skeletal metastases and have been associated with myelotoxicity. Radium-223, a first-in-class ...

INTRODUCTION A number of drugs have been shown to extend life expectancy in castration-resistant prostate cancer (CRPC). Skeletal related events (SREs) secondary to bone metastases cause significant morbidity for men with CRPC. The α-emitting radiopharmaceutical radium-223 dichloride has been shown to improve overall survival, time to symptomatic skeletal events (SSEs) and quality of life in CR...

MicroRNAs (miRNAs) are short noncoding RNAs involved in posttranscriptional regulation of gene expression and influence many cellular functions including glucose and lipid metabolism. We previously reported that adipose tissue (AT) from women with polycystic ovary syndrome (PCOS) or controls with insulin resistance (IR) revealed a differentially expressed microRNA (miRNA) profile, including upr...

The treatment scope for patients with metastatic castrate-resistant prostate cancer (mCRPC) is rapidly expanding. On May 15, 2013, the U.S. Food and Drug Administration (FDA) approved radium-223 chloride ((223)RaCl2) for the treatment of mCRPC patients whose metastases are limited to the bones. Radium-223 is an α-emitting alkaline earth metal ion, which, similar to calcium ions, accumulates in ...

Amaç: Bu çalışmayla Konya ilinde 2016-2019 arasındaki dört yıllık süreç içinde NO2 kaynaklı hava kirliliğinin mortaliteye etkisinin incelenmesi amaçlanmıştır. 
 Gereç ve Yöntem: Araştırma ekolojik tiptedir. iline ait 2016, 2017, 2018 2019 yılı nüfus ölüm verileri Türkiye İstatistik Kurumu’ndan elde edilmiştir. Hava kalitesi ölçüm istasyonu verilerinden değerlerine 01.01.2016-31.12.2019 tar...

Recent studies have demonstrated that acquisition of epithelial-to-mesenchymal transition (EMT) is associated with drug resistance in pancreatic cancer cells; however, the underlying mechanisms are not fully elucidated. Emerging evidence suggests that microRNAs play a crucial role in controlling EMT. The aims of this study were to explore the potential role of miR-223 in governing EMT in gemcit...

INTRODUCTION Approximately 10 - 20% of prostate cancer cases ultimately progress to castration-resistant prostate cancer (CRPC), for which there is a poor prognosis and a therapeutic need. Radium-223 dichloride (radium-223 [Xofigo]) is a first-in-class α-emitting radiopharmaceutical shown to significantly prolong overall survival in patients with CRPC with symptomatic bone metastases and no vis...