It is now established that specialized plasmalemmal lipid microenvironments, termed lipid rafts by Simons and Toomre,1 take part in various signal transduction processes. One subset of lipid rafts (which contain mostly cholesterol and sphingolipids) is found in plasmalemmal vesicles termed caveolae. The term caveolae (“little caves”) was introduced more than 40 years ago to describe plasma memb...

An inward rectifier potassium current, Kir, has been identified in cerebral and coronary resistance vessels, where it is considered to be an important determinant of resting membrane potential (RMP) and to play a role in blood flow regulation. We investigated the functional role of Kir in the renal afferent arteriole using the in vitro–perfused hydronephrotic rat kidney. Increasing external KCl...

Recently, the American College of Cardiology (ACC) and the American Heart Association (AHA) issued new guidelines on management of cardiovascular (CV) risk in primary prevention. They developed a new CV risk calculator [new pooled cohort atherosclerotic CV disease (CVD) risk equation] targeting individuals between 40 and 75 years and based on four American population-based cohorts. Statin treat...

Introduction Acquired haemophilia A (AHA) is a rare but clinically relevant bleeding disorder due to autoantibodies (inhibitors) against coagulation factor VIII (FVIII)1-3. AHA is usually triggered by infections, malignancies, autoimmune diseases, or pregnancy. Some cases associated with drug intake have also been described, but about half of cases remain unexplained and are classified as "idio...

Acquired hemophilia A (AHA) is a rare disorder that results from the presence of autoantibodies against the clotting factor VIII (FVIII) causing hemorrhagic disorders. This entity is mostly associated with autoimmune diseases, pregnancy, the postpartum period, drugs and malignancy. Among the solid cancers, prostate neoplasm is the most common cause of AHA. The management of AHA involves the con...

Siderophores are microbial produced low molecular weight iron chelators and strongly bind to hard Lewis acids. The siderophore desferrioxamine B (DFO) has hydroxamate functional groups, similar to acetohydroxamic acid (AHA), a ligand that is proposed for actinide complexation in advanced separations. In the proposed separation involving AHA, the exact role of the complex in the extraction behav...

The major takeaway from 2022 Heart Failure guidelines (AHA/ACC/HFSA) was the 4-pillar concept of use beta-blockers, RAAS inhibition (preferably ARNI), mineralocorticoid antagonist, and SGLT2 inhibitors (irrespective diabetes) for HFrEF. recommendations HFpEF HF mildly reduced EF are less robust. Some important heart failure trials presented every year at ACC, AHA, ESC, TCT, which can impact our...

Circulation is available at http://circ.ahajournals.org DOI: 10.1161/CIR.0b013e31829b2be6 †Deceased. The American Heart Association makes every effort to avoid any actual or potential conflicts of interest that may arise as a result of an outside relationship or a personal, professional, or business interest of a member of the writing panel. Specifically, all members of the writing group are re...

Stimulation of G protein– or tyrosine kinase–coupled receptors regulates cell proliferation through intracellular Ca ([Ca]i) signaling. In A7r5 cells, we confirmed that inositol 1,4,5-trisphosphate (IP3) mediates vasopressin (VP)-evoked Ca release from intracellular stores and showed that types 1 (IP3R1) and 3 (IP3R3) IP3 receptors were expressed. Using antisera selective for IP3R1 or IP3R3 and...

After many years of hypertext research, the Dexter model was defined [7] to capture the features of most existing hypertext systems in a single, formal reference model. Likewise, the AHAM model [5] (based on Dexter) describes most features that are found in adaptive hypermedia systems (ahs). In the AHA! project funded by the NLnet Foundation we are extending the simple AHA system [4, 6] with th...