نتایج جستجو برای: agonist 5
تعداد نتایج: 1253596 فیلتر نتایج به سال:
To assess the pharmacodynamic profile of ALEPH-2, a phenylisopropylamine derivative with alleged anxiolytic and hallucinogenic properties, Xenopus laevis oocytes were microinjected with either of the rat cRNA for the 5-HT2A or the 5-HT2C receptor. Concentration-response curves were obtained following the exposure of the oocytes to varying concentrations of either ALEPH-2 or 5-hydroxytryptamine ...
background: chronic obstructive pulmonary disease (copd) is usually considered one of the leading causes of death worldwide, so finding proper therapeutic strategies for this disease is of high importance. in this meta-analysis, we reviewed the existing literature on the efficacy and safety of conventional long acting beta agonists (labas) in copd patients. methods: we searched medline and goog...
background: release of vascular endothelial growth factor (vegf) by ovaries in response to hcg administration is one of the main mechanisms of ovarian hyper stimulation syndrome. since dopamine/dopamine receptor2 (dp-r2) pathway activity -mediated by vegf/ vascular endothelial growth factor receptor 2 (vegfr-2) signaling-, is associated with angiogenic events, dopamine agonists were used for th...
this study explored the effects of gnrh agonist (gnrha) immunity on expression of fshr mrna in pituitary and fshr protein in uteri, and also confirmed its efficacy on uterine development. 42 prepuberty and non cyclic ewes were assigned to 6 experimental groups (eg) during anestrus season. animals in eg-i, eg-ii and eg-iii were subcutaneously injected with 200, 300 and 400 μg alarelin antigens (...
conclusions our findings indicate that fenofibrate (ppar-α agonist) is able to prevent dn progression and improve kidney performance during chronic uncontrolled hyperglycemia possibly through increase in no bioavailability of kidney. results fenofibrate did not change the blood glucose of normal or diabetic rats. diabetes increased the proteinuria (82%) and blood creatinine of diabetic rats (4....
the effect of dietary terbutaline, a beta adrenergic agonist, on carcass characteristics and blood attributes in 288 japanese quails was studied from 21 through 49 days of age. dietary treatments included four levels of terbutaline [0 (t0), 1 (t1), 3 (t3), and 5 (t5) mg/kg of the diet]. quails were bled at the end of the trial for biochemical assays and the carcass characteristics were then mea...
RATIONALE The sacred lotus (Nelumbo nucifera) contains many phytochemicals and has a history of human use. To determine which compounds may be responsible for reported psychotropic effects, we used in silico predictions of the identified phytochemicals. Nuciferine, an alkaloid component of Nelumbo nucifera and Nymphaea caerulea, had a predicted molecular profile similar to antipsychotic compoun...
Reduced pregnane neurosteroids such as allopregnanolone and pregnanolone are potent neuromodulators able to affect a number of membrane receptors, including gamma-aminobutyric acid (GABA)(A), N-methyl-D-aspartate (NMDA), 5-hydroxytryptamine (5-HT)(3), and sigma(1) receptors. The present study used a drug discrimination procedure to assess further the receptor effects of pregnanolone in vivo. Ra...
Serotonin type 3 (5-HT3) receptors are members of the pentameric Cys-loop superfamily of receptors that modulate synaptic neurotransmission. In response to agonist binding and unbinding, members of this superfamily undergo a series of conformational transitions that define their functional properties. In this study, we report the results of electrophysiological studies using rapid solution exch...
Serotonin (5-hydroxytryptamine: 5-HT) is recognized as a neurotransmitter in the central nerve system and as a regulator of systemic blood pressure in the peripheral tissues. Recently, it was reported that 5-HT2 receptors (5-HT2Rs) were expressed in cartilage tissues lacking both vessels and neurons, suggesting possible novel functions of 5-HT during cartilage development and regeneration. Our ...
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