نتایج جستجو برای: afb
تعداد نتایج: 1659 فیلتر نتایج به سال:
Lin Zhu1 3, Amanda M. Schrand1, Andrey A. Voevodin4, Dong Wook Chang3, Liming Dai2 ∗, and Saber M. Hussain1 ∗ 1AFRL/711 HPW/RHPB, Wright-Patterson AFB, OH 45433-5707, USA 2Department of Chemical Engineering, Case Western Reserve University, Cleveland, OH 44106-7217, USA 3Department of Chemical and Material Engineering, University of Dayton, Dayton, OH 45409, USA 4AFRL/RXBT, Wright-Patterson AFB...
Background & Aim: Aflatoxin (AF) is the most important fungus that contaminates food and feed and can enter the food chain of humans. The aim of this study was to investigate the ability of thistle seeds (silybum marianum L.) to reduce the adverse effects of aflatoxin B1 (AFB1) on the immune system, variables related to the intestine, appearance and mortality of t...
Research on genetic influences on human fertility outcomes such as number of children ever born (NEB) or the age at first childbirth (AFB) has been solely based on twin and family-designs that suffer from problematic assumptions and practical limitations. The current study exploits recent advances in the field of molecular genetics by applying the genomic-relationship-matrix based restricted ma...
Recently we have reported that newborn rats are deficient in the key enzymes involved in the biotransformation of aflatoxin Bl (AFBl), a known hepatocarcinogen. Based on these data, in vivo experiments were carried out in order to investigate the bioavailability of this carcinogen in newborn rat tissues. Administration of a single dose (i. p.) of [3HlAFB 1 to groups of adult and neonatal r...
Human placenta and cord blood are readily available specimens that respond to maternal environmental insult and are being used to investi gate metabolism, bioactivation, and transplacental transfer of procarcinogens. Enzyme-linked immunosorbent assay was used to quantitate 120 placentas and 56 cord bloods from term, uncomplicated pregnancies at Taipei Chang Gung Memorial Hospital, Taiwan, for t...
IMPORTANCE A recently published study of national data by McGrath et al in 2014 showed increased risk of schizophrenia (SCZ) in offspring associated with both early and delayed parental age, consistent with a U-shaped relationship. However, it remains unclear if the risk to the child is due to psychosocial factors associated with parental age or if those at higher risk for SCZ tend to have chil...
Two experiments were conducted to study the efficacy of a low inclusion commercialHSCAS (Myco-Ad) in preventing the deleterious effects of Aflatoxin B1 (AFB) andOchratoxin A (OCA) in broiler chicks. Arbor Acres broiler males individually cagedwere used in both experiments. The feed was experimentally contaminated with syntheticAFB or OCA from Sigma Labs, USA. In Experiment 1, 96...
The metabolism of the carcinogenic mycotoxin aflatoxin B1 (AFB1) was examined in microsomes derived from human lymphoblastoid cell lines expressing transfected CYP1A2 or CYP3A4 complementary DNAs and in microsomes prepared from human liver donors (n = 4). Lymphoblast microsomes expressing only CYPIA2 activated AFB1 to AFBl-8,9-epoxide (AFB1-8,9-epoxide trapped as the glutathione, conjugate) at ...
Chemoprevention by chlorophyll (Chl) was investigated in a rat multi-organ carcinogenesis model. Twenty-one male F344 rats in three gavage groups (N = 7 rats each) received five daily doses of 250 microg/kg [(3)H]-aflatoxin B(1) ([(3)H]-AFB(1)) alone, or with 250 mg/kg chlorophyllin (CHL), or an equimolar amount (300 mg/kg) of Chl. CHL and Chl reduced hepatic DNA adduction by 42% (P = 0.031) an...
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