نتایج جستجو برای: af rhythm
تعداد نتایج: 48944 فیلتر نتایج به سال:
Dofetilide (Tikosyn) Dofetilide is a class III antiarrhythmic agent that prolongs the effective refractory period by blocking a single type of potassium channel (Ikr). Data were presented from 2 large efficacy trials and a mortality trial (Danish Investigation of Arrhythmia and Mortality ON Dofetilide [DIAMOND]) in support of a proposal to market an oral formulation of dofetilide for the conver...
BACKGROUND Antiarrhythmic management of atrial fibrillation (AF) remains a major clinical challenge. Mechanism-based approaches to AF therapy are sought to increase effectiveness and to provide individualized patient care. K(2P)3.1 (TASK-1 [tandem of P domains in a weak inward-rectifying K+ channel-related acid-sensitive K+ channel-1]) 2-pore-domain K+ (K(2P)) channels have been implicated in a...
BACKGROUND Atrial fibrillation (AF) is common among patients with heart failure and preserved ejection fraction (HFpEF), but its clinical profile and impact on exercise capacity remain unclear. RELAX (Phosphodiesterase-5 Inhibition to Improve Clinical Status and Exercise Capacity in HFpEF) was a multicenter randomized trial testing the impact of sildenafil on peak VO2 in stable outpatients with...
Role of AF Termination: Is There Any Difference Between Direct to Sinus Rhythm Versus Via Atrial Tachycardia? During catheter ablation of persistent atrial fibrillation (AF), the arrhythmia often organizes into a regular atrial tachyarrhythmia (AT) or directly terminates to sinus rhythm (SR). The termination of AF during ablation may be associated with higher long-term maintenance of SR, and ha...
AIMS The complex relationship between left atrial (LA) structure and function, electrical burden of atrial fibrillation (AF) and stroke risk is not well understood. We aimed to describe LA structure and function in AF. METHODS AND RESULTS Left atrial structure and function was assessed in 971 subjects enrolled in the echocardiographic substudy of ENGAGE AF-TIMI 48. Left atrial size, emptying ...
Abstract Purpose We described the incidence and ECG factors associated with de novo atrial fibrillation (AF) in patients diagnosed wild-type transthyretin cardiac amyloidosis (ATTRwt-CA) to drive tailored arrhythmia screening. Background Data on rate AF ATTRwt CA is limited. Methods Multicenter, retrospective, observational cohort study performed six referral centers for CA. All consecutive ATT...
BACKGROUND AND AIM To assess safety and efficacy of antazoline for termination of atrial fibrillation (AF) occurring during ablation of accessory pathways (AP). METHODS We analyzed electrophysiological mechanism of antazoline (changes in A-A interval) and the percentage of pre-excited QRS complexes before and after antazoline administration. The total dose administered and the time from the s...
A trial fibrillation (AF) is the most common sustained arrhythmia with 3 to 6 million currently afflicted and the prevalence expected to double by 2050. 1 AF carries an increased risk of cardiovascular morbidity and mortality driven largely by increased risk of stroke and congestive heart failure. 1 Management of AF represents a significant and growing healthcare burden, with an estimated cost ...
Introduction: Atrial fibrillation (AF) is the most prevalent cardiac arrhythmias that cardiologists and internists encounter. The goal of this article is to clarify an overview of the evidence linking inflammation to AF existence, which may highlight the effect of some pharmacological agents that have genuine potential to reduce the clinical burden of AF by modulating inflammatory pathways. Mat...
BACKGROUND Accurate echocardiographic parameters to predict maintenance of sinus rhythm in patients with atrial fibrillation (AF) are poorly defined. This study was conducted to assess the atrial myocardial properties during AF through myocardial velocity, strain rate, and strain and to compare their prognostic value in maintaining sinus rhythm in patients with lone AF with standard transthorac...
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