The adult human myocardium is incapable of regeneration; yet, the zebrafish (Danio rerio) can regenerate damaged myocardium. Similar to the zebrafish heart, hearts of neonatal, but not adult mice are capable of myocardial regeneration. We performed a proteomics analysis of adult zebrafish hearts and compared their protein expression profile to hearts from neonatal and adult mice. Using differen...

The skin is enriched in immune cells, whose cell-cell communication with parenchymal cells support functions of the skin. Particularly, innate lymphoid (ILC) distribute to epithelium for immunosurveillance and bolster epithelial barrier. However, molecular mechanisms that ILC residency their functional interactions epithelia remain incompletely understood. Here, we performed single-cell RNA-seq...

d-galactose induces pancreatic disorder along with aging mouse model. vitex agnus-castus (vac) has potential pancreatic protective effect. hence, this study was designed to evaluate the hypoglycemic and pancreas protective effects of vac hydroalcoholic extract in d-galactose-induced aging female mice. in the present experimental study, 72 adult female naval medical research institute (nmri) mic...

background: artificial stimulation of mouse oocyte, in the absence of sperm contribution, can induce its parthenogenic activation of oocyte. ultrasound is one of the newest methods for artificial activation of mammal oocytes, and its successful utilization in pig oocyte activation has been recently reported. our objective was to assess the effect of ultrasound on mouse oocyte activation. materi...

background: acceptance of uterus and reaction between endometrium and embryo has an important role for implantation. muc1 an integral membrane mucin is expressed on the apical surface of uterine epithelial cells and could have effects on its receptivity. objective: the aim of this study was to evaluate the changes in muc1 expression of gravid mouse endometrium with and without hyperstimulation ...

background: parkinson’s disease (pd) is a common neurodegenerative disease resulting from the degeneration of dopaminergic (da) neurons in the substantia nigra pars compacta (snc). increasing evidence demonstrated that mice treated intranasally with 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (mptp) suffered impairments in motor functions associated with disruption of da neurons in snc conceiv...

objective: we evaluated structural and functional changes of fresh and frozen-thawed adult mouse spermatogonial stem cells following auto-transplantation into gamma-irradiated testes. materials and methods: in this experimental research, the right testes from adult mice (n=25) were collected, then sertoli and spermatogonial cells were isolated using two-step enzymatic digestion, lectin immobili...

background:  the residual effect of triflumuron and pyriproxyfen on musca domestica l larval stages was studied in the laboratory. methods : both igrs at varying concentrations ranging between 0.5 to 2.5 mg/l were placed inside beakers with mice chow and vitamin b complex and water as food for the 1 st , 2 nd and 3 rd instars m.domestica larvae. results: both igrs inhibit m. domestica adult eme...

Mast cell-deficient W/Wv infant mice were similar to normal mice in their susceptibility to and recovery from infection with the intestinal protozoan Cryptosporidium parvum. W/Wv adult mice were significantly more susceptible to primary infection than were normal adult mice, but both groups recovered at a similar rate.

Incidence of anxiety-like disorders in humans has been shown to decrease with aging; however, it is still under debate whether there are similarities mice, which would support the use mouse models understanding neuronal network changes that regulate behavior aging. One most common tests used assess laboratory animals elevated plus maze (EPM). Although several variables, such as room brightness ...