Marked sex differences in the growth of enzyme-altered hepatic foci have been observed in rats treated according to the "resistant hepatocyte model." The present study was performed to investigate the effect of neonatal and adult castration of male rats, with or without testosterone substitution, on the growth rate of foci during selection of initiated cells with 2-acetylaminofluorene and parti...

Young rats are more sensitive than adults to a single oral dose of chlorpyrifos, an organophosphorus pesticide. A direct comparison of chlorpyrifos effects in young (postnatal day 17; PND17), adolescent (PND27), and adult (70 days) Long-Evans rats was conducted to determine quantitative and possibly qualitative differences in sensitivity in terms of behavioral changes and cholinesterase (ChE; t...

The present study was undertaken to the effect of apigenin and luteolin on physiological histological changes in rats treated with cytarabine drugs. Thirty-five albino healthy male adult equal age weighing 250 -300g were enrolled. Rats randomly divided into seven groups according treatment. Group “1” normal saline served as control group. Groups “2,3 4” received cytarabine, apigenin, respective...

Adult male rats were orchidectomized (ORX) and treated with 17β-estradiol or young coconut juice (YCJ) for ten weeks. Their femur L5 vertebra dissected, the percentage of bone volume was measured using a Micro-CT scan. Immunohistochemistry used to detect ERα ERβ determine if osteoporotic protective effects YCJ due attachment active components(s) estrogen receptors. It found that both in osteocy...

BACKGROUND We previously reported that adult female, but not male rats that were prenatally exposed to methamphetamine exhibit myocardial hypersensitivity to ischemic injury. However, it is unknown whether hypersensitivity to ischemic injury develops when rats are exposed to methamphetamine during adulthood. The goal of this study was to determine whether methamphetamine exposure during adultho...

Present study to investigate the effects of lindane in steroidogenesis and testis tissues of adult male albino rat. Adult male rats were orally administered with lindane at a dose of 5.0mg/kg body weight per day for 30 days, the rat were killed using anesthetic ether, plasma was collected and testis were removed histopathological studies. Male albino rats were treated with lindane, decreased th...

Background: Enzymatic and histological change in the testicular cells of rats treated orally, intraperitoneally and intradermally for 45 days with Gibberellic acid (GBA) in independent studies is reported. This study was conducted to evaluate in vitro fertilization (IVF) rate and preimplantation embryonic development in GBA treated adult male rats. Materials and Methods: Thirty six adult male W...