نتایج جستجو برای: adrenocorticotropin hormone
تعداد نتایج: 142873 فیلتر نتایج به سال:
Human blood contains an inactive proteolytic enzyme, plasminogen, which may be converted in vitro to its active form, plasmin, either spontaneously or by the addition of various agents (1). A similar activation is believed to occur in vivo after exposure to a variety of noxious circumstances (2-6). Since plasmin catalyzes the hydrolysis of corticotropin A (7), it is possible that circumstances ...
The functions of the phosphodiesterase 8B (PDE8) family of phosphodiesterases have been largely unexplored because of the unavailability of selective pharmacological inhibitors. Here, we report a novel function of PDE8B as a major regulator of adrenal steroidogenesis using a genetically ablated PDE8B mouse model as well as cell lines treated with either a new PDE8-selective inhibitor or a short...
Cortistatin (CST) and somatostatin (SST) evolve from a common ancestral gene and share remarkable structural, pharmacological, and functional homologies. Although CST has been considered as a natural SST-analogue acting through their shared receptors (SST receptors 1-5), emerging evidence indicates that these peptides might in fact exert unique roles via selective receptors [e.g. CST, not SST, ...
OBJECTIVE Evaluation of factors influencing the outcome of microsurgical transsphenoidal surgery in patients harbouring pituitary adenomas as well as of the efficacy and safety of this procedure. DESIGN A total of 184 consecutive patients with pituitary adenomas, undergoing microsurgical transsphenoidal resection of their lesions from March 2004 to June 2011, were prospectively studied. Exten...
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