OBJECTIVE Patients with incidental nonfunctioning adrenal adenoma are associated with increased risk of obesity, impaired glucose tolerance and dyslipidemia. We aimed to investigate the relationship between thyroid function, serum lipids and insulin resistance in patients with nonfunctioning adrenal incidentaloma. SUBJECTS AND METHODS Forty patients who had diagnosed as adrenal incidentaloma ...

the presence of tumor thrombus in the right atrium is frequently the result of direct intraluminal extension of infra-diaphragmatic malignancy into the inferior vena cava (ivc) or supradiaphragmatic carcinoma into the superior vena cava (svc). right atrial tumor thrombus with extension into both svc and ivc has not been reported in the literature. we present a patient who presented with symptom...

Patients with chronic disorders of consciousness (CDoC) have various variants the pathological organization functions including sympathetic hyperactivity and hormonal changes. The objective: to determine severity paroxysmal (PSH), function pituitary-adrenal system in patients CDoC. Subjects Methods. 54 CDoC were enrolled study. randomized groups depending on assessment Coma Recovery Scale-Revis...

Using immunoperoxidase methods, 94 human adrenal tumors were examined for evidence of immunoreactivity and receptor expression of insulinlike growth factor I (IGF-I) and insulin. The frequency of IGF-I in adrenocortical carcinomas was significantly higher than that in adenomas of the adrenal glands. The adrenocortical carcinomas showed strong intensity of staining for IGF-I, IGF-I receptors, an...

Many physiological processes and most endocrine functions show fluctuations over the course of the day. These so-called circadian rhythms are governed by an endogenous network of cellular clocks and serve as an adaptation to daily and, thus, predictable changes in the organism's environment. Circadian clocks have been described in several tissues of the stress axis and in adipose cells where th...

Mutations in the PKD2 gene account for ∼15% of all cases of autosomal-dominant polycystic kidney disease. In the present study the cellular distribution of the Pkd2 protein was investigated by immunohistochemistry in different rat organs. Although the Pkd2 protein showed a widespread expression, a strikingly different distribution of the protein was observed between individual organs. Whereas i...

Increasing biochemical evidence suggests that the renin-angiotensin system may be present in may extrarenal tissues. We have employed the mouse submandibular gland renin complementary DNA (pDD-1D2) and the rat liver angiotensinogen complementary DNA (pRang 3) to demonstrate that renin and angiotensinogen messenger RNAs are expressed in the mouse kidney, submandibular gland, heart, adrenal, brai...

Circadian clocks are endogenous oscillators driving daily rhythms in physiology. The cell-autonomous clock is governed by an interlocked network of transcriptional feedback loops. Hundreds of clock-controlled genes (CCGs) regulate tissue specific functions. Transcriptome studies reveal that different organs (e.g. liver, heart, adrenal gland) feature substantially varying sets of CCGs with diffe...

Rat adrenal mitochondria have an active rotenone-insensitive outer mitochondrial membrane NADH-semidehydroascorbate (NADH-SDA) reductase which supports cholesterol side chain cleavage at a rate equal to that supported by malate. Side chain cleavage activity supported by both of these electron donor systems is equally inhibited by cycloheximide. Catalase or butylated hydroxyanisole are required ...

Adrenal failure causes a complex disturbance of renal function and of sodium and water exchange. In the dog, as in man, the ability to conserve sodium is impaired (1, 2), there is a fall in glomerular filtration rate and renal blood flow (3-6), and diuresis from water ingestion is much delayed (7, 8). There have been many reports of the effects of corticosteroids on discrete renal functions suc...