Spontaneous neoplasms in 930 control Wistar rats from five carcinogenicity bioassays conducted between 1990 and 1995 were reviewed and compared with review findings in studies between 1980 and 1990. Mean survival at 104 weeks was 55% for males and 60% for females, similar to that of the previous review. A total of 1599 neoplasms was diagnosed in 361 (78%) male and 415 (89%) female rats; 1293 (8...

AIMS To investigate the immunohisto-chemical staining of normal, hyperplastic, and neoplastic adrenal cortex with a monoclonal antibody against alpha inhibin. Also, to determine whether immunostaining with this antibody is useful in differentiating between adrenal cortical neoplasms and other tumours involving the adrenal gland that might mimic them. METHODS Normal adrenal tissue (n = 20) and...

The adrenal gland comprises the cortex, responsible for the production of steroid hormones, and the medulla, producing the catecholamines norepinephrine and epinephrine. Both of these components can show hyperplastic and neoplastic change. This presentation will outline relevant aspects of normal structure and function. Then, with respect to the adrenal cortex, the various types of hyperplasia ...

Background Cortisol plays a role in the regulation of metabolic homeostasis. Dexamethasone is powerful synthetic glucocorticoid that acts as an anti-inflammatory and immunosuppressive agent. Plasma free cortisol, which has low concentration blood, cortisol fraction provides biological activity. It emphasized measurement dexamethasone, total levels can directly affect results dexamethasone suppr...