adefovir dipivoxil

Alessandra Maciel Almeida Andréia Queiroz Ribeiro Cristiane Aparecida Menezes de Pádua Cristina Mariano Ruas Brandão Eli Iôla Gurgel Andrade Mariângela Leal Cherchiglia Ricardo Andrade Carmo Francisco de Assis Acurcio

INTRODUCTION Chronic hepatitis B is one of the most frequent infectious disease in the world and represents a serious problem of public health METHODS A systematic review of randomized clinical trials was conducted to evaluate the efficacy of the nucleoside/nucleotide analogues (adefovir, entecavir and telbivudine) used for the treatment of chronic hepatitis B. The databases PubMed and LILACS...

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Deep Sequencing Analysis of HBV Genotype Shift and Correlation with Antiviral Efficiency during Adefovir Dipivoxil Therapy

2015

Yuwei Wang Xuefeng Shan Zhi Liang Youlan Shan Wenxiang Huang Dazhi Zhang Aizhong Zen Xin Zhou Yao Zhao Xuyang Gong Ge Xu Xiuyu Zhang Juan Chen Ailong Huang Haitao Guo

BACKGROUND Viral genotype shift in chronic hepatitis B (CHB) patients during antiviral therapy has been reported, but the underlying mechanism remains elusive. METHODS 38 CHB patients treated with ADV for one year were selected for studying genotype shift by both deep sequencing and Sanger sequencing method. RESULTS Sanger sequencing method found that 7.9% patients showed mixed genotype bef...

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