Escherichia coli expresses two DNA repair methyltransferases (MTases) that repair the mutagenic O6-methylguanine (O6MeG) and O4-methylthymine (O4MeT) DNA lesions; one is the product of the inducible ada gene, and here we confirm that the other is the product of the constitutive ogt gene. We have generated various ogt disruption mutants. Double mutants (ada ogt) do not express any O6MeG/O4MeT DN...

BACKGROUND We tested the concordance of the two diagnostic criteria for diabetes using fasting plasma glucose (FPG) and hemoglobin A1c (HbA1c) by the Japan Diabetes Society (JDS) and American Diabetes Association (ADA). METHODS We used data from 7,328 subjects without known diabetes who participated in a voluntary health checkup program at least twice between 1998 and 2006, at intervals ≤ 2 y...

Human adenosine deaminase (ADA) is a purine catabolic enzyme that catalyzes the irreversible hydrolytic deamination of adenosine and deoxyadenosine. The enzyme is broadly distributed in human tissues with highest activity in lymphoid Adenosine deaminase purified from human erythrocytes is a soluble monomeric protein with an estimated molecular weight of about 38,000 daltons that exhibits post-t...

OBJECTIVE To evaluate the impact of adalimumab (ADA) dose-halving on therapeutic responses and drug levels, the differences in drug levels among patients with different therapeutic responses and the optimal baseline cut-off ADA levels for predicting persistent remission or low disease activity (LDA) at week 24 of dose-halving therapy in 64 RA patients who had already achieved LDA or remission a...

OBJECTIVE Adenosine deaminase (ADA) may be multifunctional, regulating adenosine levels and adenosine receptor (AR) agonism, and potentially modifying AR functionality. Herein we assess effects of ADA (and A1AR) deficiency on AR-mediated responses and ischaemic tolerance. METHODS Normoxic function and responses to 20 or 25 min ischaemia and 45 min reperfusion were studied in isolated hearts f...

Guardol is a domain-specific language designed to facilitate the construction of correct network guards operating over treeshaped data. The Guardol system generates Ada code from Guardol programs and also provides specification and automated verification support. Guard programs and specifications are translated to higher order logic, then deductively transformed to a form suitable for a SMT-sty...

In this paper, we propose a new technique used to design a robust controller that is not as high-order and complicated as the ones designed by conventional Η∞ loop shaping method. To overcome the problem we proposed an algorithm called Genetic Algorithm (GA) based fixed-structure Η∞ loop shaping control. In the approach, GA is adopted to solve the Η∞ loop shaping design problem under a structur...

Abstract Introduction: Myocardial Infarction, also known as heart attack, normally occurs due to such causes as smoking, family history, diabetes, and so on. It is recognized as one of the leading causes of death in the world. Therefore, the present study aimed to evaluate the performance of classification models in order to predict Myocardial Infarction, using a feature selection method tha...

BACKGROUND Adenosine deaminase (ADA) is useful in the diagnosis of tuberculous pleural effusion (TPE). This study aims to determine the factors affecting pleural fluid ADA levels and to establish the optimal ADA levels for diagnosis of TPE for different age groups. METHODS This was a retrospective study from January 2007 to October 2011. One hundred and sixty patients who had pleural fluid AD...