Neurogenic pulmonary edema (NPE) is an acute life-threatening complication following an injury of the spinal cord or brain, which is associated with sympathetic hyperactivity. The role of nitric oxide (NO) in NPE development in rats subjected to balloon compression of the spinal cord has not yet been examined. We, therefore, pretreated Wistar rats with the NO synthase inhibitor N(G)-nitro-L-arg...

background: the present study was designed to evaluate the secondary microglial activation processes after spinal cord injury (sci). methods: a quantitative histological study was performed to determine ed-1 positive cells, glial cell density, and cavitation size in untreated sci rats at days 1, 2, and 4, and weeks 1, 2, 3, and 4. results: the results of glial cell quantification along the 4900...

objectives: although for those spinal cord injury (sci) patients with paralysis of the legs but not at arms, the primary means of mobility post injury is the manual wheelchair, there are many physiological and psychological advantages to standing and walking, such as improvement in respiratory function, lower limb weight bearing and preventing osteoporosis, pressure sores prevention etc. high m...

background: bone marrow stromal cells (bmsc) have been successfully employed for movement deficit recovery in spinal cord injury (sci) rat models. one of the unsettled problems in cell transplantation is the relative high proportion of cell death, specifically after neural differentiation. according to our previous studies, p75 receptor, known as the death receptor, is only expressed in bmsc in...

this descriptive study was aimed to identify how provided nursing care related to physical problems caused by traction and cast in patients with fracture and dislocation in cervical spinal cord in educational hospitals of tehran university of medical sciences. samples, including 46 patients were recruited from neurosurgery and orthopedic wards, and also from neurosurgical intensive care units d...

spinal cord injury (sci)-induced systemic inflammatory response affects multiple organs outside the spi­nal cord. treatment options for such complications are lacking. valproic acid (vpa) is a histone deacetylase inhibitor, acting directly at the level of gene transcription by inhibiting histone deacetylation and making transcription sites more accessible. acetylation of histones is critical to...

the purpose of this study was to shed light on the identification of themes and sub-themes of the quality of life (qol) in iranian veterans with spinal cord injury (sci). studies have reported decreased qol in sci patients which encompass all aspects of their life. little is known about qol in sci veterans from iran. the aim of this qualitative study was to identify related aspects of such pati...

prior animal models have shown that rats sustaining 3-second immediate spinal cord compression had significantly better functional recovery and smaller lesion volumes than rats subjected to compression times of 1 hour, 6 hours, 3 weeks, and 10 weeks after spinal cord injury. we compare locomotor rating scales and spinal cord histopathology after 3 seconds and 10 minute compression times. . ten ...

background: health-related quality-of-life (hr-qol) may be affected by various factors including injury-related characteristics among individuals with spinal cord injury (sci). however, the impact of the influence of these variables has not yet been fully described in iranian population. here, we assessed the relationships between injury-related characteristics and hr-qol among iranian people w...

background in recent decades, the incidence of spinal cord injuries has increased. in a systemic review on epidemiology of traumatic spinal cord injury in developing countries reported 25.5/million cases per year. objectives to assess the quality of life (qol) of the veterans among iran-iraq war with chronic spinal cord injuries (sci) and to evaluate long-term impressions of sci on their qualit...