objectives: mangifera indica (mango) is used in folk medicine for treatment of different types of diseases, and its anti-inflammatory and free radical scavenging activities have been demonstrated. the present study evaluated the effects of commercial (vimang) and hydroalcoholic extract of mango on gentamicin-induced nephrotoxicity in rat. materials and methods: female wistar rats were treated w...

acute renal failure is one of the side effects while using intravenous immunoglobulins. this complication is also observed with iodinated contrast media. herein, we describe a patient with acute renal failure who received intravenous immunoglobulins and iodinated contrast media concomitantly. both drugs are responsible for osmotic nephrosis. the same effect on renal cells may explain a synergis...

Ischemia-reperfusion injury (IRI) is the major cause of acute renal failure in native and allograft kidneys. Identifying the molecules and pathways involved in the pathophysiology of renal IRI will yield valuable new diagnostic and therapeutic information. To identify differentially regulated genes in renal IRI, RNA from rat kidneys subjected to an established renal IRI protocol (bilateral occl...

BACKGROUND To analyze survival, neurologic injury, and kidney function after acute type A aortic dissection. METHODS A total of 445 patients undergoing surgery for acute type A aortic dissection were analyzed. Evaluation according to risk factors for mortality, neurologic injury, and kidney function was performed. RESULTS Overall 1-, 5-, and 10-year survival rates were 82.8 ± 1.8%, 73.6 ± 2...

BACKGROUND Acute kidney injury is a common and devastating complication of critical illness, for which renal replacement therapy is frequently needed to manage severe cases. While a recent systematic review suggested that "earlier" initiation of renal replacement therapy improves survival, completed trials are limited due to small size, single-centre status, and use of variable definitions to d...

Acute kidney injury in patients with chronic renal failure is a common scenario in clinical practice. In many cases, the cause is obvious, as in urinary tract infection, dehydration, use of non-steroidal anti-inflammatory drugs or recent therapeutic manipulation of the renin–angiotensin– aldosterone system. In some cases, however, the acute element can be more difficult to identify or remain el...

introduction renal tubular acidosis (rta) is a non-uremic defects of urinary acidification. it is characterized by a normal anion gap hyperchloremic  metabolic acidosis; plasma potassium may be normal, low or high-depending on the type of rta. these syndromes differ from uremic acidosis which is associated with a high anion gap, decreased glomerular filtration with enhanced proton secretion by ...

Considerable attention is directed to a surprising biologic phenomenon wherein tissues exposed to one insult acquire resistance to another. We identify a novel example of acquired resistance to acute renal failure and a mechanism that contributes to such resistance. Nephrotoxic serum, administered to rats 24 h before the induction of glycerol-induced acute renal failure, reduces functional and ...

Acute kidney injury is a clinical syndrome characterized by a loss of renal function and acute tubular necrosis. Resveratrol exerts a wide range of pharmacological effects based on its anti‑inflammatory, antioxidant and cytoprotective properties. The present study aimed to evaluate whether resveratrol attenuates acute kidney injury in a cisplatin‑induced rat model and to investigate the potenti...