Previous studies of acute generalized exanthematous pustulosis, a peculiar drug hypersensitivity reaction, suggested that CXCL8-producing T cells regulate sterile, polymorphonuclear neutrophil-rich skin inflammations. In this study, we test the hypothesis of whether CXCL8-producing T cells are present in autoinflammatory diseases like pustular psoriasis and Behçet's disease. Immunohistochemistr...

A 68-year-old man presented with a generalized papular eruption with oedema of the face and the hands, fever and pustulosis in intertriginous areas which had begun 1 day after starting treatment with EuvanolA nasal spray (plant extracts and benzalkonium chloride) and DolirhumA (paracetamol and pseudoephedrine). He has been hospitalized 8 years before for a similar eruption associated with hyper...

Abstract We report a case of an unusually located site acute localized exanthematous pustulosis in the right lower limb patient treated with beta‐lactams which resolved upon cessation. This highlights need for vigilance as well index suspicion atypical presentations.

AGEP: acute generalized exanthematous pustulosis BCC: basal cell carcinoma SJS/TEN: Stevens-Johnson syndrome/toxic epidermal necrolysis INTRODUCTION Basal cell carcinoma (BCC) is a common skin neoplasm that usually has a nonaggressive behavior typically managed with local treatment (eg, surgery, photodynamic treatment, topical agents, or radiation). In some cases, BCC has a much more invasive b...

In evaluation of medication allergy, the utility of drug patch testing is dependent on both the type of drug reaction and the suspected causal drug. Epicutaneous patch tests reproduce T cell-mediated delayed hypersensitivity; thus, eruptions at least partially mediated by T cells can be confirmed by positive drug patch test (DPT) responses in some patients. These include acute generalized exant...

Severe cutaneous adverse reactions (SCARs) are generally induced by drugs and encompass the conditions of Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN), drug induced eosinophilia and systemic syndrome (DRESS) also known as drug induced hypersensitivity syndrome (DIHS), and acute generalized exanthematous pustulosis (AGEP). These conditions, although rare, cause significant...