Acute hemorrhagic encephalomyelitis (AHEM) is the most severe form of acute disseminated (ADEM). Patients with AHEM usually have unfavorable outcomes high mortality rate. We reported a middle-aged male, who was diagnosed and died 35 days after admission even under intensive immune therapy. Clinical courses were recorded serial MR images demonstrated to illustrate rapidly changes in brain parenc...

Acute disseminated encephalomyelitis (ADEM) is an autoimmune demyelinating disorder of the central nervous system and can present following influenza A infections as multifocal neurological deficits. ADEM remains a challenging diagnosis, and high clinical suspicious coupled with laboratory investigations and neuroimaging is required to exclude other primary and secondary demyelinating disorders.

The differential diagnosis between multiple sclerosis and acute disseminated encephalomyelitis has major prognostic and therapeutic implications for the patient. As originally defined, acute disseminated encephalomyelitis is an acute monophasic disease that requires early anti-inflammatory treatment, whereas long-term immunomodulatory therapies are considered unnecessary due to the self-limitin...

recommend that the PaO, should be checked about two hours after starting the first period of therapy and the flow rate adjusted accordingly. Follow-up of patients for up to two years has shown that they are still asymptomatic and free of disease (P. Forgacs, personal communication). For many years the aetiology of pneumatosis coli has been a matter for debate. The introduction of oxygen as a su...

The differential diagnosis between multiple sclerosis and acute disseminated encephalomyelitis has major prognostic and therapeutic implications for the patient. As originally defined, acute disseminated encephalomyelitis is an acute monophasic disease that requires early anti-inflammatory treatment, whereas long-term immunomodulatory therapies are considered unnecessary due to the self-limitin...

A 50-year-old non-diabetic woman was admitted for hemorrhagic diathesis. Laboratory examination indicated that she was suffering from t(15;17)-positive acute promyelocytic leukemia associated with disseminated intravascular coagulation. She was started on all-trans retinoic acid plus idarubicin and cytarabine. However, due to the development of retinoic acid syndrome, all-trans retinoic acid wa...

Investigators from Ruth Children's Hospital, Haifa, and Schneider Medical Center, Petah Tikuah, Israel, evaluated the long-term motor and neurocognitive outcome of 43 children hospitalized during 2002-2012 with acute disseminated encephalomyelitis (ADEM), and identified prognostic risk factors.

The differential diagnosis between multiple sclerosis and acute disseminated encephalomyelitis has major prognostic and therapeutic implications for the patient. As originally defined, acute disseminated encephalomyelitis is an acute monophasic disease that requires early anti-inflammatory treatment, whereas long-term immunomodulatory therapies are considered unnecessary due to the self-limitin...

Inherent abnormalities of myelin have been suggested in the pathogenesis of multiple sclerosis (MS). We investigated myelin in acute disseminated encephalomyelitis (ADEM) patients by magnetic resonance spectroscopy (MRS) and cerebrospinal fluid (CSF) analysis for citrulline, a marker of immature myelin. A citrulline peak was observed in the normal appearing white matter of 7/15 patients and of ...

PURPOSE OF REVIEW In this review, the possible etiology, clinical characteristics, diagnosis, and treatment of acute disseminated encephalomyelitis (ADEM) are discussed. ADEM is a para- or postinfectious autoimmune demyelinating disease of the central nervous system and has been considered a monophasic disease. The highest incidence of ADEM is observed during childhood. RECENT FINDINGS Over t...