CLINICAL PHARMACOLOGY Sulfasalazine is split by bacterial action in the colon into sulfapyridine (SP) and mesalamine (5-ASA). It is thought that the mesalamine component is therapeutically active in ulcerative colitis. The usual oral dose of sulfasalazine for active ulcerative colitis in adults is 2 to 4 g per day in divided doses. Four grams of sulfasalazine provide 1.6 g of free mesalamine to...

The smaller subparticle of rabbit reticulocyte ribosomes was shown to yield core-particle and split-protein fractions on treatment with 2.5 M-NH4Cl/61 mM-MgCl2. The core-particle fraction was inactive in poly(U)-directed polyphenylalanine synthesis, but activity was restored after recombination with the split-protein fraction. Optimum ionic conditions for the reconstruction of active subparticl...

Cores were prepared from 50S ribosomal subunits by incubation with 0.4 M LiCl/Mg(++) (0.4c cores); 0.8c cores and corresponding SP(0.4-0.8) split proteins were obtained from 0.4c cores. In the fragment reaction 0.4c cores were active, but 0.8c cores were not. Activity of the 0.8c cores could be restored by reconstitution with the SP(0.4-0.8) fraction. The split proteins were separated by DEAE-c...

In order to investigate the effect of the pressure buffer gas and frequency on the output power, a copper vapor laser with active medium length of 60 cm and bore of 16 mm has been operated and optimized using air as a buffer gas. The observed oscillatory behavior of the output power versus frequency is in good agreement with the previous reports. The measured results show the maximum output pow...

We present an optical method for patterning SERS (surface-enhanced Raman spectroscopy)--enhancing aggregates of gold nanoparticles, using a focused laser beam to optically trap the nanoparticles in suspension. At high laser powers, heat generated from the plasmonic excitation causes boiling of the aqueous suspension and the formation of gaseous bubbles of water vapor. By measuring the Raman pea...

MRPC is an RPC system that is designed and optimized for MPMD parallel computing. Existing systems based on standard RPC incur an unnecessarily high cost when used on high-performance multi-computers, limiting the appeal of RPC-based languages in the parallel computing community. MRPC combines the efficient control and data transfer provided by Active Messages (AM) with a minimal multithreaded ...

This technical report describes the design, implementation, and evaluation of Active Messages on the IBM SP-2. The implementation benchmarked here uses the standard TB2 network adapter rmware but does not use any IBM software on the Power2 processor. We assume familiarity with the concepts underlying Active Messages. The main performance characteristics are a one-word message round-trip time of...

A collaborative approach, involving resources and expertise from several countries, was used to develop a test cell to measure cumulative permeation by a solid-state collection technique. The new technique was developed to measure the permeation of pesticide active ingredients and other chemicals with low vapor pressure that would otherwise be difficult to test via standard techniques. The deve...