The modulation of canonical macroautophagy/autophagy for therapeutic benefit is an emerging strategy of medical and pharmaceutical interest. Many drugs act to inhibit autophagic flux by targeting lysosome function, while others were developed to activate the pathway. Here, we report the surprising finding that many therapeutically relevant autophagy modulators with lysosomotropic and ionophore ...

LIRs are immunoglobulinlike receptors that have activating and inhibitory functions in leukocytes. Here we report the identification of the first LIR family member, LIR9, expressed as a membrane-bound receptor and as a secreted molecule. We identified 4 different forms of LIR9, 2 of which encode transmembrane molecules and 2 encode secreted molecules. The transmembrane forms of LIR9 contain a s...

Autophagy regulation is important for tumor cell survival. Activation and inhibition of autophagy can sensitize tumor cells to anticancer drugs. However, few autophagy-regulating small molecules are available to increase the efficacy of anticancer drugs. Here, we report that 2,2'-methylenebis (6-tert-butyl 4-methylphenol), hereafter referred to as methylenebis, is a novel autophagy-regulating s...

Background Oncogenic activation and HIF-1 overexpression stimulate glycolysis in part by activating the bifunctional 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatases (PFKFB1-4) that synthesize fructose-2,6-bisphosphate (F2,6BP), an allosteric activator of 6-phosphofructo-1kinase (PFK-1), which is an essential control point in the glycolytic pathway. Although PFKFB3 is considered the domina...

NK cell education is the process through which chronic engagement of inhibitory NK cell receptors by self MHC-I molecules preserves cellular responsiveness. The molecular mechanisms responsible for NK cell education remain unclear. Here, we show that mouse NK cell education is associated with a higher basal activity of the mTOR/Akt pathway, commensurate to the number of educating receptors. Thi...

Abstract: Dissolution and recovery of Mn-Al compacts with and without a chloride flux was studied by taking samples from the melt after addition of the compact. Events occurring after the addition of the compacts into the melt were studied using water quenched specimens after holding them for a specified time in molten state. The cross sections of these specimens were characterized by SEM a...

Chemotherapy-induced peripheral neuropathy (CIPN) is a debilitating side effect of many cancer treatments. The hallmark of CIPN is degeneration of long axons required for transmission of sensory information; axonal degeneration causes impaired tactile sensation and persistent pain. Currently the molecular mechanisms of CIPN are not understood, and there are no available treatments. Here we show...

background: hemodialysis is a process of removing waste and excess fluid from blood when kidneys cannot function efficiently. it often involves diverting blood to the filter of the dialysis machin to be cleared of toxic substances. fouling of pores in dialysis membrane caused by adhesion of plasma protein and other toxins will reduce the efficacy of the filtre. objective: in this study, the inf...

beer is the most consumed beverage after tea, carbonates, milk and coffee in the world and it continues to be a popular drink. one of the important reason for its popularity is that beer is a drink with a pleasant flavor, an attractive color and also because of its clarity. so, membrane separation technology has become widely used in the food processing industryto attain these characteristics.a...

this study examines the transport of seventeen heavy metals between the isipingo estuary andthe adjacent sea. results demonstrate variability of fluxes in terms of prevalence, concentration and seasonality.summer neap and spring tides had approximately twice the number of heavy metals compared to winter andspring seasons. spring and winter seasons yielded higher concentrations and a greater num...