نتایج جستجو برای: actin β
تعداد نتایج: 223906 فیلتر نتایج به سال:
Antimicrobial peptides exist in the non-specific immune system of organism and participate in the innate host defense of each species. CecropinXJ, a cationic antimicrobial peptide, possesses potent anticancer activity and acts preferentially on cancer cells instead of normal cells, but the mechanism of cancer cell death induced by cecropinXJ remains largely unknown. This study was performed to ...
for gene transfer research and studies of cell differentiation and regulation of gene expression. Identification of the genomic structure of fish genes provides valuable sequence information and adds to understanding of their molecular evolution. We aimed at cloning rainbow trout regulatory sequences that direct expression of genes in skeletal muscle. To address this task, we chose α-actin, myo...
Spontaneous Ca2+ transients and actin dynamics in primary motoneurons correspond to cellular differentiation such as axon elongation and growth cone formation. Brain-derived neurotrophic factor (BDNF) and its receptor trkB support both motoneuron survival and synaptic differentiation. However, in motoneurons effects of BDNF/trkB signaling on spontaneous Ca2+ influx and actin dynamics at axonal ...
23 Meprins, metalloproteinases abundantly expressed in the brush border membranes 24 (BBMs) of rodent proximal kidney tubules, have been implicated in the pathology of 25 renal injury induced by ischemia reperfusion (IR). Disruption of the meprin β gene, and 26 actinonin, a meprin inhibitor, both decrease kidney injury resulting from IR. To date, the 27 in vivo kidney substrates for meprins are...
The actin cytoskeleton is highly conserved among eukaryotes and is essential for cellular processes regulating growth and differentiation. In fungi, filamentous actin (F-actin) orchestrates hyphal tip structure and extension via organization of exocytic and endocytic processes at the hyphal tip. Although highly conserved, there are key differences among actins of fungal species as well as betwe...
Autologous submandibular gland transplantation is an effective treatment for severe dry eye syndrome. However, the protein secretion in transplanted gland is altered by a mechanism that remains to be elucidated. In the present study, we found that β1-adrenoceptor (β1-AR) and β2-AR expression and the phosphorylation of the downstream molecule protein kinase A (PKA) were elevated in transplanted ...
The localization of specific mRNAs and polyribo-somes within growth cones may permit a direct response to external signals and rapidly influence cy-cones was regulated by both age in culture and calcium (Crino and Eberwine, 1997). -actin mRNAs localized Bronx, New York 10461 rapidly to growth cones in response to NT-3, a response which required microtubules and cAMP-dependent protein kinase A ...
The process of epithelial-mesenchymal transition (EMT) in response to transforming growth factor-β (TGF-β) contributes to tissue fibrosis, wound healing, and cancer via a mechanism that is not fully understood. This study identifies a critical role of JunB in the EMT and profibrotic responses to TGF-β. Depletion of JunB by small interfering ribonucleic acid abrogates TGF-β-induced disruption of...
The genus Phoma Sacc. consists of important fungal plant pathogenic species occurring on economically important cultivated crops in spite of many other saprobic species. Thus, the aim of this study was to identify 35 isolates of Phoma species and related taxa collected from different hosts by means of morphological and molecular characters. Multi-locus phylogenetic analyses based on ITS1-5.8S-I...
Dendritic spines are dynamic, actin-rich structures that form the postsynaptic sites of most excitatory synapses in the brain. The F-actin severing protein cofilin has been implicated in the remodeling of dendritic spines and synapses under normal and pathological conditions, by yet unknown mechanisms. Here we report that β-arrestin-2 plays an important role in NMDA-induced remodeling of dendri...
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